NAPSA

Napsin-A is an aspartic proteinase that is encoded in humans by the NAPSA gene.[5] The name napsin comes from novel aspartic proteinase of the pepsin family.[6]

NAPSA
Identifiers
AliasesNAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin A aspartic peptidase
External IDsOMIM: 605631 MGI: 109365 HomoloGene: 68418 GeneCards: NAPSA
Orthologs
SpeciesHumanMouse
Entrez

9476

16541

Ensembl

ENSG00000131400

ENSMUSG00000002204

UniProt

O96009

O09043

RefSeq (mRNA)

NM_004851

NM_008437

RefSeq (protein)

NP_004842

NP_032463

Location (UCSC)Chr 19: 50.36 – 50.37 MbChr 7: 44.22 – 44.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[5]

Utility

Detection of NAPSA gene expression can be used to distinguish adenocarcinomas from other forms of lung cancer.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000131400 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002204 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NAPSA napsin A aspartic peptidase".
  6. Tatnell, Peter J; Powell, David J; Hill, Jeffrey; Smith, Trudi S; Tew, David G; Kay, John (11 December 1998). "Napsins: new human aspartic proteinases". FEBS Letters. 441 (1): 43–48. doi:10.1016/s0014-5793(98)01522-1. PMID 9877162. S2CID 27656626.
  7. Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma". Br. J. Cancer. 88 (8): 1229–33. doi:10.1038/sj.bjc.6600879. PMC 2747556. PMID 12698189.

Further reading


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