Naringenin 8-dimethylallyltransferase

In enzymology, a naringenin 8-dimethylallyltransferase (EC 2.5.1.70) is an enzyme that catalyzes the chemical reaction

dimethylallyl diphosphate + (-)-(2S)-naringenin diphosphate + sophoraflavanone B
Naringenin 8-dimethylallyltransferase
Identifiers
EC no.2.5.1.70
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are dimethylallyl diphosphate and (-)-(2S)-naringenin, whereas its two products are diphosphate and sophoraflavanone B.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is dimethylallyl-diphosphate:naringenin 8-dimethylallyltransferase. This enzyme is also called N8DT.

References

    • Yamamoto H, Senda M, Inoue K (2000). "Flavanone 8-dimethylallyltransferase in Sophora flavescens cell suspension cultures". Phytochemistry. 54 (7): 649–55. doi:10.1016/S0031-9422(00)00198-9. PMID 10975499.
    • Zhao P, Inoue K, Kouno I, Yamamoto H (2003). "Characterization of leachianone G 2"-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait cell suspension cultures". Plant Physiol. 133 (3): 1306–13. doi:10.1104/pp.103.025213. PMC 281625. PMID 14551337.


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