Nasuia deltocephalinicola

Nasuia deltocephalinicola was reported in 2013 to have the smallest genome of all bacteria, with 112,091 nucleotides.[1] For comparison, the human genome has 3.2 billion nucleotides.[2] The second smallest genome, from bacteria Tremblaya princeps, has 139,000 nucleotides. While N. deltocephalinicola has the smallest number of nucleotides, it has more protein-coding genes (137)[1] than some bacteria.[3]

Nasuia deltocephalinicola
Scientific classification
Domain:
Bacteria
Phylum:
Pseudomonadota
Class:
Betaproteobacteria
Genus:
Nasuia
Species:
N. deltocephalinicola
Binomial name
Nasuia deltocephalinicola

Symbiotic relationship

N. deltocephalinicola was discovered when leafhoppers and other phloem- and xylem-feeding insects were investigated for endosymbiotic bacteria.[3] The phloem and xylem of plants are rich in carbohydrates (in the form of sucrose) but lack lipids and proteins. Lipids can be synthesized from carbohydrates; however, proteins require nitrogen, which is not commonly found in plant sap.[4] N. deltocephalinicola along with other bacterial endosymbionts help the insects by synthesizing 10 essential amino acids that they would not otherwise have. The only insects that can benefit from this relationship are those from the suborder Sternorrhyncha, which feed off phloem, and those from the suborder Auchenorrhyncha, which feed off xylem. N. deltocephalinicola can synthesize two of the essential amino acids that these insects require. N. deltocephalinicola uses the UGA codon in its DNA to specify tryptophan instead of the stop as in most other organisms.[1]

The symbiotic relationship between N. deltocephalinicola and leafhoppers is proposed to have started at least 200 million years ago, when leafhoppers and spittlebugs diverged evolutionarily. This claim is supported by the fact that N. deltocephalinicola's closest bacterial relative is Zinderia insecticola, which plays the same role for spittlebugs as N. deltocephalinicola does in leafhoppers.[1] Leafhoppers return the favor by providing shelter in the form of a specialized organ in their abdominal cavity called a bacteriome, which they have on both sides of their abdomens. Many types of bacteria can reside in these organs, though the bacteria are completely separated from each other and reside in different sections of the bacteriome.[4]

N. deltocephalinicola is an obligate endosymbiont—it cannot thrive without being in a leafhopper. It is an intracellular endosymbiont, living within bacteriocytes, cells that are specialized for housing endosymbiotic bacteria.[5] These bacteriocytes comprise an organ called a bacteriome, whose cells host a variety of bacterial endosymbionts.[5] Intracellular endosymbionts may evolve to depend on the host cells for essential cellular functions. As a result, their genomes often lack genes that would be required for life in an extracellular environment, even one containing abundant nutrients.[6] They have thereby begun the process of evolving from a free-living organism to an intracellular organelle. N. deltocephalinicola also no longer has genes needed to synthesize ATP through oxidative phosphorylation.[4] It is proposed that this is because of the high sucrose concentration found in xylem and phloem of plants.[1]

See also

References
  1. Kirchberger, Paul C.; Schmidt, Marian L.; Ochman, Howard (2020-09-08). "The Ingenuity of Bacterial Genomes". Annual Review of Microbiology. Annual Reviews. 74 (1): 815–834. doi:10.1146/annurev-micro-020518-115822. ISSN 0066-4227.
    Bennett, Gordon M.; Moran, Nancy A. (31 July 2013). "Small, smaller, smallest: the origins and evolution of ancient dual symbioses in a phloem-feeding insect". Genome Biology and Evolution. Oxford Journals. 5 (9): 1675–1688. doi:10.1093/gbe/evt118. PMC 3787670. PMID 23918810. Archived from the original on 2 June 2014.
  2. Brown, Terrence A. (2002). "Genomes". National Center for Biotechnology Information. Oxford: Wiley-Liss.
  3. Zimmer, Carl (23 August 2013). "And the Genomes Keep Shrinking..." National Geographic. National Geographic Magazine.
  4. Ishii, Yoshiko; Matsuura, Yu; Kakizawa, Shigeyuki; Nikoh, Naruo; Fukatsu, Takema (August 2013). "Diversity of Bacterial Endosybionts Associated with Macrosteles Leafhoppers Vectoring Phytopathogenic Phytoplasmas". Applied and Environmental Microbiology. 79 (16): 5013–5022. doi:10.1128/aem.01527-13. PMC 3754707. PMID 23770905.
  5. Noda, Hiroaki; Watanabe, Kenji; Kawai, Sawako; Yukohiro, Fumiko; Miyoshi, Takaharu (2012-06-04). "Bacteriome-associated endosymbionts of the green rice leafhopper Nephotettix cincticeps (Hemiptera: Cicadellidae)". Applied Entomology and Zoology. 47 (3): 217–225. doi:10.1007/s13355-012-0110-1. S2CID 18485847. Retrieved 2021-03-15.
  6. Bennett, Gordon M.; Moran, Nancy A. (2013). "Small, Smaller, Smallest: The Origins and Evolution of Ancient Dual Symbioses in a Phloem-Feeding Insect". Genome Biology and Evolution. 5 (9): 1675–1688. doi:10.1093/gbe/evt118. ISSN 1759-6653. PMC 3787670. PMID 23918810.
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