Nathaniel Kleitman

Nathaniel Kleitman was born in Chișinău, also known as Kishinev, the capital of the province of Bessarabia (now Moldova), in 1895 to a Jewish family. He was deeply interested in consciousness and reasoned that he could get insight in consciousness by studying the unconsciousness of sleep.[3] Pogroms drove him to Palestine, and in 1915 he emigrated to the United States as a result of World War I. At the age of twenty, he landed in New York City penniless; in 1923, at age twenty-eight, he had worked his way through City College of New York and earned a PhD from the University of Chicago's Department of Physiology. His thesis was "Studies on the physiology of sleep." Soon after, in 1925, he joined the faculty there. An early sponsor of Kleitman's sleep research was the Wander Company, which manufactured Ovaltine and hoped to promote it as a remedy for insomnia.

Eugene Aserinsky, one of Kleitman's graduate students, decided to hook sleepers up to an early version of an electroencephalogram machine, which scribbled across 1⁄2 mile (800 m) of paper each night. In the process, Aserinsky noticed that several times each night the sleepers went through periods when their eyes darted wildly back and forth. Kleitman insisted that the experiment be repeated yet again, this time on his daughter, Esther. In 1953, he and Aserinsky introduced the world to "rapid-eye movement," or REM sleep. Kleitman and Aserinsky demonstrated that REM sleep was correlated with dreaming and brain activity. Another of Kleitman's graduate students, William C. Dement, who was a professor of psychiatry at the Stanford medical school, described this as the year that "the study of sleep became a true scientific field."

Kleitman made countless additional contributions to the field of sleep research and was especially interested in "rest-activity" cycles, leading to many fundamental findings on circadian and ultradian rhythms. Kleitman proposed the existence of a Basic rest activity cycle, or BRAC, during both sleep and wakefulness.[4][5]

Renowned for his personal and experimental rigor, he conducted well-known sleep studies underground in Mammoth Cave, Kentucky and lesser-known studies underwater in submarines during World War II and above the Arctic Circle.[6]