Natural antisense short interfering RNA

Natural antisense short interfering RNA (natsiRNA) is a type of siRNA. They are endogenous RNA regulators which are between 21 and 24 nucleotides in length, and are generated from complementary mRNA transcripts which are further processed into siRNA.[1]

natsiRNA has been implicated in several developmental and response mechanisms in plants, such as pathogen resistance,[2] salt tolerance [3] and cell wall biosynthesis.[4] natsiRNA has also been shown to alter gene expression in plants responding to environmental stressors.[5]

References
  1. Moldovan, D.; Spriggs, A.; Dennis, E. S.; Wilson, I. W. (2010). "The hunt for hypoxia responsive natural antisense short interfering RNAs". Plant Signaling & Behavior. 5 (3): 247–251. doi:10.4161/psb.5.3.10548. PMC 2881268. PMID 20009576.
  2. Katiyar-Agarwal, S.; Morgan, R.; Dahlbeck, D.; Borsani, O.; Villegas, A.; Zhu, J. -K.; Staskawicz, B. J.; Jin, H. (2006). "A pathogen-inducible endogenous siRNA in plant immunity". Proceedings of the National Academy of Sciences. 103 (47): 18002–18007. doi:10.1073/pnas.0608258103. PMC 1693862. PMID 17071740.
  3. Borsani, O.; Zhu, J.; Verslues, P. E.; Sunkar, R.; Zhu, J. K. (2005). "Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis". Cell. 123 (7): 1279–1291. doi:10.1016/j.cell.2005.11.035. PMC 3137516. PMID 16377568.
  4. Held, M. A.; Penning, B.; Brandt, A. S.; Kessans, S. A.; Yong, W.; Scofield, S. R.; Carpita, N. C. (2008). "Small-interfering RNAs from natural antisense transcripts derived from a cellulose synthase gene modulate cell wall biosynthesis in barley". Proceedings of the National Academy of Sciences. 105 (51): 20534–20539. doi:10.1073/pnas.0809408105. PMC 2603254. PMID 19075248.
  5. Zhang, Xiaoming; Xia, Jing (22 March 2012). "Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function". Genome Biology. 13 (20): R20. doi:10.1186/gb-2012-13-3-r20. PMC 3439971. PMID 22439910.


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