Neuroserpin

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.[5]

SERPINI1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSERPINI1, PI12, neuroserpin, serpin family I member 1, HNS-S2, HNS-S1
External IDsOMIM: 602445 MGI: 1194506 HomoloGene: 21045 GeneCards: SERPINI1
Orthologs
SpeciesHumanMouse
Entrez

5274

20713

Ensembl

ENSG00000163536

ENSMUSG00000027834

UniProt

Q99574

O35684

RefSeq (mRNA)

NM_005025
NM_001122752

NM_009250
NM_001357514

RefSeq (protein)

NP_001116224
NP_005016

NP_033276
NP_001344443

Location (UCSC)Chr 3: 167.74 – 167.83 MbChr 3: 75.46 – 75.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][5]

Interactions

SERPINI1 has been shown to interact with Tissue plasminogen activator.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000163536 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027834 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1".
  6. Parmar, Parmjeet K; Coates Leigh C; Pearson John F; Hill Rena M; Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. 82 (6): 1406–15. doi:10.1046/j.1471-4159.2002.01100.x. ISSN 0022-3042. PMID 12354288. S2CID 23571680.

Further reading

  • The MEROPS online database for peptidases and their inhibitors: I04.025
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