Neurotrimin

NTM
Identifiers
Aliases	NTM, HNT, IGLON2, NTRI, neurotrimin, CEPU-1
External IDs	OMIM: 607938 MGI: 2446259 HomoloGene: 41139 GeneCards: NTM
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	132,336,822 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	29,874,437 bp[2]
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; middle temporal gyrus; ; postcentral gyrus; ; Brodmann area 23; ; superior frontal gyrus; ; corpus callosum; ; Brodmann area 9; ; entorhinal cortex; ; prefrontal cortex; ; amygdala;
	Top expressed in
	primary motor cortex; ; visual cortex; ; cerebellar cortex; ; cerebellar vermis; ; superior frontal gyrus; ; prefrontal cortex; ; mammillary body; ; lateral geniculate nucleus; ; barrel cortex; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	anchored component of membrane; membrane; extracellular region; plasma membrane;
Biological process	neuron recognition; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	50863
	235106
	ENSG00000182667
	ENSMUSG00000059974
	Q9P121
	Q99PJ0
NM_001048209; NM_001144058; NM_001144059; NM_016522; NM_001352001;
	NM_001352002; NM_001352003; NM_001352004; NM_001352005; NM_001352006; NM_001352007; NM_001352008; NM_001352009
NM_172290; NM_001357593; NM_001357597; NM_001357598; NM_001357601;
	NM_001357602; NM_001357603
NP_001041674; NP_001137530; NP_001137531; NP_057606; NP_001338930;
	NP_001338931; NP_001338932; NP_001338933; NP_001338934; NP_001338935; NP_001338936; NP_001338937; NP_001338938
NP_758494; NP_001344522; NP_001344526; NP_001344527; NP_001344530;
	NP_001344531; NP_001344532
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotrimin is a protein that in humans is encoded by the NTM gene.[5][6]

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML) on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.[6]

References

GRCh38: Ensembl release 89: ENSG00000182667 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059974 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci. 15 (3 Pt 2): 2141–56. doi:10.1523/JNEUROSCI.15-03-02141.1995. PMC 6578143. PMID 7891157.
"Entrez Gene: HNT neurotrimin".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer". Nat. Genet. 34 (3): 337–43. doi:10.1038/ng1183. PMID 12819783. S2CID 24411276.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Liu J, Li G, Peng X, et al. (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene". Science in China Series C: Life Sciences. 47 (2): 158–64. doi:10.1360/03yc0072. PMID 15379248. S2CID 12684887.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182667 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059974 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7891157-5] Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL (Apr 1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules". J Neurosci. 15 (3 Pt 2): 2141–56. doi:10.1523/JNEUROSCI.15-03-02141.1995. PMC 6578143. PMID 7891157.

[entrez-6] "Entrez Gene: HNT neurotrimin".

Neurotrimin

References

Further reading