Nitrate reductase (quinone)

Nitrate reductase (quinone) (EC 1.7.5.1, nitrate reductase A, nitrate reductase Z, quinol/nitrate oxidoreductase, quinol-nitrate oxidoreductase, quinol:nitrate oxidoreductase, NarA, NarZ, NarGHI) is an enzyme with systematic name nitrite:quinone oxidoreductase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

nitrate + a quinol nitrite + a quinone + H2O
Nitrate reductase (quinone)
Identifiers
EC no.1.7.5.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This is a membrane-bound enzyme which supports [anaerobic respiration] on nitrate.

References
  1. Enoch HG, Lester RL (December 1974). "The role of a novel cytochrome b-containing nitrate reductase and quinone in the in vitro reconstruction of formate-nitrate reductase activity of E. coli". Biochemical and Biophysical Research Communications. 61 (4): 1234–41. doi:10.1016/s0006-291x(74)80416-x. PMID 4616697.
  2. Bertero MG, Rothery RA, Palak M, Hou C, Lim D, Blasco F, Weiner JH, Strynadka NC (September 2003). "Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A". Nature Structural Biology. 10 (9): 681–7. doi:10.1038/nsb969. PMID 12910261.
  3. Lanciano P, Magalon A, Bertrand P, Guigliarelli B, Grimaldi S (May 2007). "High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD". Biochemistry. 46 (18): 5323–9. doi:10.1021/bi700074y. PMID 17439244.
  4. Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC (April 2005). "Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A". The Journal of Biological Chemistry. 280 (15): 14836–43. doi:10.1074/jbc.M410457200. PMID 15615728.
  5. Bonnefoy V, Demoss JA (1994). "Nitrate reductases in Escherichia coli". Antonie van Leeuwenhoek. 66 (1–3): 47–56. doi:10.1007/bf00871632. PMID 7747940.
  6. Guigliarelli B, Asso M, More C, Augier V, Blasco F, Pommier J, Giordano G, Bertrand P (July 1992). "EPR and redox characterization of iron-sulfur centers in nitrate reductases A and Z from Escherichia coli. Evidence for a high-potential and a low-potential class and their relevance in the electron-transfer mechanism". European Journal of Biochemistry. 207 (1): 61–8. doi:10.1111/j.1432-1033.1992.tb17020.x. PMID 1321049.
  7. Iobbi-Nivol C, Santini CL, Blasco F, Giordano G (March 1990). "Purification and further characterization of the second nitrate reductase of Escherichia coli K12". European Journal of Biochemistry. 188 (3): 679–87. doi:10.1111/j.1432-1033.1990.tb15450.x. PMID 2139607.
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