Nitroalkane oxidase
In enzymology, a nitroalkane oxidase (EC 1.7.3.1) is an enzyme that catalyzes the chemical reaction
- a nitroalkane + H2O + O2 an aldehyde or ketone + nitrite + H2O2
| nitroethane oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.7.3.1 | ||||||||
| CAS no. | 9029-36-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are nitroalkane, H2O, and O2, whereas its 4 products are aldehyde, ketone, nitrite, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor. The systematic name of this enzyme class is nitroalkane:oxygen oxidoreductase. Other names in common use include nitroethane oxidase, NAO, and nitroethane:oxygen oxidoreductase. This enzyme participates in nitrogen metabolism.
References
- LITTLE HN (1951). "Oxidation of nitroethane by extracts from Neurospora". J. Biol. Chem. 193 (1): 347–58. doi:10.1016/S0021-9258(19)52460-7. PMID 14907722.
- Kido T, Hashizume K, Soda K (1978). "Purification and properties of nitroalkane oxidase from Fusarium oxysporum". J. Bacteriol. 133 (1): 53–8. doi:10.1128/jb.133.1.53-58.1978. PMC 221975. PMID 22538.
- Daubner SC, Gadda G, Valley MP, Fitzpatrick PF (2002). "Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2702–7. doi:10.1073/pnas.052527799. PMC 122411. PMID 11867731.
- Fitzpatrick PF, Orville AM, Nagpal A, Valley MP (2005). "Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase". Arch. Biochem. Biophys. 433 (1): 157–65. doi:10.1016/j.abb.2004.08.021. PMID 15581574.
- Valley MP, Tichy SE, Fitzpatrick PF (2005). "Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase". J. Am. Chem. Soc. 127 (7): 2062–6. doi:10.1021/ja043542f. PMC 1630679. PMID 15713081.
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