NsiR4 small RNA
NsiR4 (nitrogen stress-induced RNA 4), former name SyR12, is a cyanobacterial non-coding RNA which plays role in the regulation of Glutamine synthetase (GS), a key enzyme in biological nitrogen assimilation. NsiR4 interacts with the 5′UTR of the mRNA of the GS inactivating factor IF7 (gifA mRNA) and reduces its expression. NsiR4 expression is under positive control of the nitrogen control transcription factor (NtcA). NsR4 is a first example of an sRNA controlling the assimilation of a micronutrient.[1]
| NsiR4 sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of PinT small RNA | |
| Identifiers | |
| Rfam | RF002677 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0010608 |
| SO | SO:0000370 |
| PDB structures | PDBe |
References
- Klähn S, Schaal C, Georg J, Baumgartner D, Knippen G, Hagemann M, Muro-Pastor AM, Hess WR (November 2015). "The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7". Proceedings of the National Academy of Sciences of the United States of America. 112 (45): E6243–6252. Bibcode:2015PNAS..112E6243K. doi:10.1073/pnas.1508412112. PMC 4653137. PMID 26494284.
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