Nucleolar and spindle associated protein 1
Nucleolar and spindle associated protein 1 is a protein that in humans is encoded by the NUSAP1 gene. [5]
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| Aliases | NUSAP1, ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL, nucleolar and spindle associated protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612818 MGI: 2675669 HomoloGene: 10207 GeneCards: NUSAP1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009].
References
- GRCh38: Ensembl release 89: ENSG00000137804 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000027306 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Nucleolar and spindle associated protein 1". Retrieved 2018-05-22.
Further reading
- Wadia PP, Coram M, Armstrong RJ, Mindrinos M, Butte AJ, Miklos DB (March 2010). "Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation". Blood. 115 (10): 2077–87. doi:10.1182/blood-2009-03-211375. PMC 2837325. PMID 20053754.
- Verbakel W, Carmeliet G, Engelborghs Y (August 2011). "SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction". Biochem. Biophys. Res. Commun. 411 (4): 732–7. doi:10.1016/j.bbrc.2011.07.015. PMID 21782797.
- Chou HY, Wang TH, Lee SC, Hsu PH, Tsai MD, Chang CL, Jeng YM (December 2011). "Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis". Cell Cycle. 10 (23): 4083–9. doi:10.4161/cc.10.23.18200. PMID 22101338.
- Gulzar ZG, McKenney JK, Brooks JD (January 2013). "Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1". Oncogene. 32 (1): 70–7. doi:10.1038/onc.2012.27. PMC 3360134. PMID 22349817.
- Espinosa AM, Alfaro A, Roman-Basaure E, Guardado-Estrada M, Palma Í, Serralde C, Medina I, Juárez E, Bermúdez M, Márquez E, Borges-Ibáñez M, Muñoz-Cortez S, Alcántara-Vázquez A, Alonso P, Curiel-Valdez J, Kofman S, Villegas N, Berumen J (2013). "Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer". PLOS ONE. 8 (2): e55975. Bibcode:2013PLoSO...855975E. doi:10.1371/journal.pone.0055975. PMC 3566100. PMID 23405241.
- Kotian S, Banerjee T, Lockhart A, Huang K, Catalyurek UV, Parvin JD (May 2014). "NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels". Cancer Biol. Ther. 15 (5): 533–43. doi:10.4161/cbt.28019. PMC 4026076. PMID 24521615.
- Chen L, Yang L, Qiao F, Hu X, Li S, Yao L, Yang XL, Shao ZM (2015). "High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer". PLOS ONE. 10 (10): e0140572. Bibcode:2015PLoSO..1040572C. doi:10.1371/journal.pone.0140572. PMC 4618922. PMID 26485712.
- Okamoto A, Higo M, Shiiba M, Nakashima D, Koyama T, Miyamoto I, Kasama H, Kasamatsu A, Ogawara K, Yokoe H, Tanzawa H, Uzawa K (2015). "Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma". PLOS ONE. 10 (11): e0142252. Bibcode:2015PLoSO..1042252O. doi:10.1371/journal.pone.0142252. PMC 4640814. PMID 26554377.
- Li C, Zhang Y, Yang Q, Ye F, Sun SY, Chen ES, Liou YC (January 2016). "NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity". Sci Rep. 6: 18773. Bibcode:2016NatSR...618773L. doi:10.1038/srep18773. PMC 4702128. PMID 26733216.
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