Olfactomedin-like 3

Olfactomedin-like protein 3 is a protein that in humans is encoded by the OLFML3 gene.[5] It has been shown to act as a proangiongenic factor in the tumor microenvironment, being released by endothelial cells and pericytes.[6]

OLFML3
Identifiers
AliasesOLFML3, HNOEL-iso, OLF44, olfactomedin like 3
External IDsOMIM: 610088 MGI: 1914877 HomoloGene: 10613 GeneCards: OLFML3
Orthologs
SpeciesHumanMouse
Entrez

56944

99543

Ensembl

ENSG00000116774

ENSMUSG00000027848

UniProt

Q9NRN5

Q8BK62

RefSeq (mRNA)

NM_020190
NM_001286352
NM_001286353

NM_133859

RefSeq (protein)

NP_001273281
NP_001273282
NP_064575
NP_064575.1

NP_598620

Location (UCSC)Chr 1: 113.98 – 114.04 MbChr 3: 103.63 – 103.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene has also been associated with pectinate ligament dysplasia and glaucoma in Border Collies.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000116774 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027848 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OLFML3 olfactomedin-like 3".
  6. Miljkovic-Licina M, Hammel P, Garrido-Urbani S, Lee BP, Meguenani M, Chaabane C, et al. (December 2012). "Targeting olfactomedin-like 3 inhibits tumor growth by impairing angiogenesis and pericyte coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi:10.1158/1535-7163.MCT-12-0245. PMID 23002094.
  7. Oliver JA, Wright H, Massidda PA, Burmeister LM, Mellersh CS (January 2020). "A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom". Veterinary Ophthalmology. 23 (1): 25–36. doi:10.1111/vop.12680. PMID 31141290. S2CID 169036374.

Further reading

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