OSBPL8

OSBPL8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V88
Identifiers
Aliases	OSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDs	OMIM: 606736 MGI: 2443807 HomoloGene: 68813 GeneCards: OSBPL8
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	76,559,809 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	111,133,110 bp[2]
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; lactiferous duct; ; cancellous bone; ; endothelial cell; ; nipple; ; Achilles tendon; ; visceral pleura; ; trigeminal ganglion; ; superficial temporal artery; ; external globus pallidus;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; secondary oocyte; ; cumulus cell; ; olfactory epithelium; ; myocardium of ventricle; ; retinal pigment epithelium; ; interventricular septum; ; aortic valve; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylserine binding; cholesterol binding; phosphatidylinositol-4-phosphate binding; lipid binding; phospholipid transporter activity; sterol transporter activity; sterol binding;
Cellular component	integral component of membrane; nuclear membrane; endoplasmic reticulum membrane; membrane; cortical endoplasmic reticulum; endoplasmic reticulum; nucleus; cytosol; intracellular membrane-bounded organelle;
Biological process	activation of protein kinase B activity; positive regulation of protein kinase B signaling; lipid transport; protein localization to nuclear pore; phospholipid transport; negative regulation of cell migration; negative regulation of sequestering of triglyceride; positive regulation of insulin receptor signaling pathway; fat cell differentiation; phosphatidylserine acyl-chain remodeling; transport; sterol transport; positive regulation of glucose import;
	Sources:Amigo / QuickGO
Orthologs
	114882
	237542
	ENSG00000091039
	ENSMUSG00000020189
	Q9BZF1
	B9EJ86
	NM_001003712; NM_020841; NM_001319652; NM_001319653; NM_001319655
	NM_001003717; NM_175489
	NP_001003712; NP_001306581; NP_001306582; NP_001306584; NP_065892
	NP_001003717; NP_780698
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.[5][6][7]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

GRCh38: Ensembl release 89: ENSG00000091039 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020189 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pritchett JW (Mar 1992). "Longitudinal growth and growth-plate activity in the lower extremity". Clin Orthop Relat Res. 275 (275): 274–9. doi:10.1097/00003086-199202000-00041. PMID 1735225.
Yan D, Mayranpaa MI, Wong J, Perttila J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (Dec 2007). "OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages". J Biol Chem. 283 (1): 332–40. doi:10.1074/jbc.M705313200. PMID 17991739.
"Entrez Gene: OSBPL8 oxysterol binding protein-like 8".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
Lehto M, Laitinen S, Chinetti G, et al. (2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091039 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020189 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1735225-5] Pritchett JW (Mar 1992). "Longitudinal growth and growth-plate activity in the lower extremity". Clin Orthop Relat Res. 275 (275): 274–9. doi:10.1097/00003086-199202000-00041. PMID 1735225.

[pmid17991739-6] Yan D, Mayranpaa MI, Wong J, Perttila J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (Dec 2007). "OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages". J Biol Chem. 283 (1): 332–40. doi:10.1074/jbc.M705313200. PMID 17991739.

[entrez-7] "Entrez Gene: OSBPL8 oxysterol binding protein-like 8".

OSBPL8

References

Further reading