OSTalpha

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the SLC51A gene.[5][6]

SLC51A
Identifiers
AliasesSLC51A, OSTA, OSTalpha, solute carrier family 51 alpha subunit, solute carrier family 51 subunit alpha, PFIC6
External IDsOMIM: 612084 MGI: 2146634 HomoloGene: 44941 GeneCards: SLC51A
Orthologs
SpeciesHumanMouse
Entrez

200931

106407

Ensembl

ENSG00000163959

ENSMUSG00000035699

UniProt

Q86UW1

Q8R000

RefSeq (mRNA)

NM_152672

NM_145932

RefSeq (protein)

NP_689885

NP_666044

Location (UCSC)Chr 3: 196.21 – 196.24 MbChr 16: 32.29 – 32.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000163959 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035699 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OSTalpha organic solute transporter alpha".
  6. Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
  7. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.
  8. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. Bibcode:2008PNAS..105.3891R. doi:10.1073/pnas.0712328105. PMC 2268840. PMID 18292224.

Further reading


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