Oviduct-specific glycoprotein

Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein, oviductin or mucin-9 is a protein that in humans is encoded by the OVGP1 gene.[5][6][7]

OVGP1
Identifiers
AliasesOVGP1, CHIT5, EGP, MUC9, OGP, oviductal glycoprotein 1
External IDsOMIM: 603578 MGI: 106661 HomoloGene: 74442 GeneCards: OVGP1
Orthologs
SpeciesHumanMouse
Entrez

5016

12659

Ensembl

ENSG00000085465

ENSMUSG00000074340

UniProt

Q12889

Q62010

RefSeq (mRNA)

NM_002557

NM_007696

RefSeq (protein)

NP_002548

NP_031722

Location (UCSC)Chr 1: 111.41 – 111.43 MbChr 3: 105.88 – 105.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.[7]

Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland [8] OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000085465 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074340 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Arias EB, Verhage HG, Jaffe RC (Feb 1995). "Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein". Biol Reprod. 51 (4): 685–94. doi:10.1095/biolreprod51.4.685f. PMID 7819450.
  6. Lapensee L, Paquette Y, Bleau G (Nov 1997). "Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)". Fertil Steril. 68 (4): 702–8. doi:10.1016/S0015-0282(97)00317-8. PMID 9341614.
  7. "Entrez Gene: OVGP1 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin)".
  8. Laheri, Saniya; Modi, Deepak; Bhatt, Purvi (Mar 2017). "Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary". Journal of Biosciences. 42 (1): 69–80. doi:10.1007/s12038-016-9657-2. PMID 28229966. S2CID 10274575. Retrieved 16 July 2018.
  9. Laheri, Saniya; Ashary, Nancy; Bhatt, Purvi; Modi, Deepak (2018). "Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion". Journal of Assisted Reproduction and Genetics. 35 (8): 1419–1429. doi:10.1007/s10815-018-1231-4. PMC 6086790. PMID 29968069.

Sources

Further reading

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