Ohio State Route 643

SR 643 begins at a T-intersection with SR 83 in rural Coshocton County. The highway heads northwest, before turning northeast. The road passes through farmland, with some woodlands and houses. The route enters New Bedford and has an intersection with SR 651. The highway leaves New Bedford and continues towards the northwest, before turning easterly. The road makes a sharp curve towards the north. After turning due north, the route has a T-intersection with SR 557. SR 557 heads west and SR 643 heads east from the T-intersection. SR 643 heads east-northeast, before its northern terminus at a T-intersection with SR 93.[5][6][7][8]

The highway between SR 651 and SR 557 is inclusive in the Amish Country Byway, an officially designated National Scenic Byway.[9] The route is not included in the National Highway System.[10] SR 557 has its lowest traffic counts; within the 2011 ODOT survey, the road is listed with an average annual daily traffic (AADT) of 830 vehicles on a section of highway between SR 651 and Holmes County line. ODOT figured that the peak traffic levels were present on the section that is between SR 557 and SR 93, where 1,350 vehicles used the highway daily.[11]

SR 643 was commissioned in 1937, on most of the same route as today. The northern terminus of SR 643 was about 0.5 miles (0.80 km) south of the current intersection at SR 93.[3][4] In 1949, the northern terminus was at Temporary SR 557, when Temporary SR 557 was commissioned.[12][13] Between 1953 and 1955, SR 557 was paved, in Holmes County.[14][15] The route in Coshocton County was paved between 1957 and 1961.[16][17] The Temporary SR 557 was removed by 1969 and SR 643 was extended to the current intersection with SR 557. SR 643 replaced SR 557 from that intersection to SR 93.[18] No significant changes have taken place to this state route since 1969.[6][18]