Ole Kiehn

Ole Kiehn (born 1958) is a Danish-Swedish neuroscientist.[1] He is Professor of Integrative Neuroscience at the Department of Neuroscience, University of Copenhagen, Denmark, and professor of neurophysiology at Karolinska Institute, Sweden.[2][3]

Ole Kiehn
Danish - Swedish neuroscientist
Born1958 (age 64–65)
Nakskov, Denmark
NationalityDanish-Swedish
Occupation(s)Neuroscientist and professor

Early life and education

Ole Kiehn is born 1958 in Nakskov, Denmark. He earned his medical degree in 1985 and his Doctorate in Science (D.Sci.) in 1990, both from University of Copenhagen, Denmark.[1]

Career

From 1985-89 Kiehn worked as a research associate at the Institute of Neurophysiology, University of Copenhagen.[1] He spent 1989-90 working as a Postdoc at the Section of Neurobiology and Behavior at Cornell University, US, before returning to Denmark to become a group leader at the Institute of Neurophysiology at University of Copenhagen (1991–95). From 1995 to 2000, he was employed as a Hallas Møller Research Fellow at Department of Physiology, University of Copenhagen, and in 1997 he became associate professor at the same place, a position that he held until he was recruited to Karolinska Institute in Sweden in 2001. Since 2004, Ole Kiehn is working as professor in neuroscience at the Department of Neuroscience at Karolinska Institute. From 2003 to 2011 he was deputy chair of the Department of Neuroscience, Karolinska Institute. In 2008 Kiehn became a member of the Nobel Assembly at the Karolinska Institute and after serving as an adjunct member from 2011–14, he was elected as a member of the Nobel Committee for Physiology or Medicine in 2014 to 2019.[4]

Since 2017, Ole Kiehn is also employed as professor in Integrative Neuroscience at the Department of Neuroscience, University of Copenhagen. Since 2019, Kiehn is co-editor in chief of Current Opinion in Neurobiology.[5]

Work

Kiehn has published over 120 original papers and reviews and his work has been reported in scientific journals, including Nature (journal), Science (journal), Cell (journal), Nature Neuroscience, Neuron (journal), PNAS, Nature Reviews Neuroscience among others. Kiehn’s work has elucidated the functional organization of neuronal circuits controlling movement. In his initial work he showed that vertebrate motor neurons can express transmitter-modulated plateau potentials.[6] His continued work has shown an involvement of plateaux in disturbed motor symptoms seen after spinal cord injury.[7] Using molecular mouse genetic, electrophysiology and behavioral studies he has revealed the key cellular organization of spinal locomotor networks and was able to functionally discover and link specific neuronal populations in the spinal cord to the ability to produce the alternating movements between limbs during locomotion[8][9][10][11] and to set the rhythm of locomotion.[12][13] Kiehn has also discovered specific populations of excitatory brainstem neurons that mediate the episodic control of locomotion: the start and stop of locomotion as well as turning.[14][12] These studies unravel the communication pathway between the brain and the spinal cord needed to control the expression of locomotion.

Awards and honors

References
  1. Kiehn, Ole (October 2, 2017). "CV". in.ku.dk.
  2. University of Copenhagen, Department of Neuroscience (January 29, 2019). "Kiehn Lab". in.ku.dk.
  3. "Kiehn Laboratory". ki.se.
  4. The Nobel Committee for Physiology or Medicine
  5. Editorial board of Current Opinion in Neurobiology
  6. Hounsgaard, J.; Hultborn, H.; Jespersen, B.; Kiehn, O. (November 22, 1988). "Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan". The Journal of Physiology. 405: 345–367. doi:10.1113/jphysiol.1988.sp017336. PMC 1190979. PMID 3267153.
  7. Bellardita, C.; Caggiano, V.; Leiras, R.; Caldeira, V.; Fuchs, A.; Bouvier, J.; Löw, P.; Kiehn, O. (2017). "Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice. - PubMed - NCBI". eLife. 6: e23011. doi:10.7554/eLife.23011. PMC 5332159. PMID 28191872.
  8. Talpalar, Adolfo E.; Endo, Toshiaki; Löw, Peter; Borgius, Lotta; Hägglund, Martin; Dougherty, Kimberly J.; Ryge, Jesper; Hnasko, Thomas S.; Kiehn, Ole (22 September 2011). "Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. - PubMed - NCBI". Neuron. 71 (6): 1071–1084. doi:10.1016/j.neuron.2011.07.011. PMID 21943604. S2CID 16945911.
  9. Talpalar, Adolfo E.; Bouvier, Julien; Borgius, Lotta; Fortin, Gilles; Pierani, Alessandra; Kiehn, Ole (August 1, 2013). "Dual-mode operation of neuronal networks involved in left-right alternation". Nature. 500 (7460): 85–88. Bibcode:2013Natur.500...85T. doi:10.1038/nature12286. PMID 23812590. S2CID 4427401.
  10. Butt, Simon J. B.; Kiehn, Ole (June 19, 2003). "Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals". Neuron. 38 (6): 953–963. doi:10.1016/s0896-6273(03)00353-2. PMID 12818180. S2CID 17633931.
  11. Kullander, Klas; Butt, Simon J. B.; Lebret, James M.; Lundfald, Line; Restrepo, Carlos E.; Rydström, Anna; Klein, Rudiger; Kiehn, Ole (March 21, 2003). "Role of EphA4 and EphrinB3 in local neuronal circuits that control walking". Science. 299 (5614): 1889–1892. Bibcode:2003Sci...299.1889K. doi:10.1126/science.1079641. PMID 12649481. S2CID 9275050.
  12. Bouvier, Julien; Caggiano, Vittorio; Leiras, Roberto; Caldeira, Vanessa; Bellardita, Carmelo; Balueva, Kira; Fuchs, Andrea; Kiehn, Ole (November 19, 2015). "Descending Command Neurons in the Brainstem that Halt Locomotion". Cell. 163 (5): 1191–1203. doi:10.1016/j.cell.2015.10.074. PMC 4899047. PMID 26590422.
  13. Hägglund, Martin; Borgius, Lotta; Dougherty, Kimberly J.; Kiehn, Ole (February 22, 2010). "Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion". Nature Neuroscience. 13 (2): 246–252. doi:10.1038/nn.2482. PMID 20081850. S2CID 5347394.
  14. Caggiano, V.; Leiras, R.; Goñi-Erro, H.; Masini, D.; Bellardita, C.; Bouvier, J.; Caldeira, V.; Fisone, G.; Kiehn, O. (January 25, 2018). "Midbrain circuits that set locomotor speed and gait selection". Nature. 553 (7689): 455–460. Bibcode:2018Natur.553..455C. doi:10.1038/nature25448. PMC 5937258. PMID 29342142.
  15. Brain Prize 2022
  16. "Hjerneforsker hædres for kortlægning af neuronale netværk, der kontrollerer motorik". 8 October 2021.
  17. University of Copenhagen, Department of Neuroscience (December 20, 2019). "Ole Kiehn receives DKK 32 million to research integrated neural circuits". in.ku.dk.
  18. "Pioneering Neuroscientist Awarded Novo Nordisk Foundation Laureate Research Grant". Novo Nordisk Foundation News.
  19. "ERC Advanced Grants 2015 Results" (PDF).
  20. "EMBO". EMBO.
  21. "Academy of Europe: Kiehn Ole". www.ae-info.org.
  22. The Royal Swedish Academy of Sciences homepage
  23. "Videnskabernes Selskab | Royal Academy". www.royalacademy.dk.
  24. The Royal Swedish Academy of Sciences News
  25. "ERC Advanced Grants 2010 - Winners". ERC: European Research Council. January 20, 2011.
  26. "IRP Schellenberg Research Prize". www.irp.ch.
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