Olfactomedin-like 3
Olfactomedin-like protein 3 is a protein that in humans is encoded by the OLFML3 gene.[5] It has been shown to act as a proangiongenic factor in the tumor microenvironment, being released by endothelial cells and pericytes.[6]
| OLFML3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | OLFML3, HNOEL-iso, OLF44, olfactomedin like 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610088 MGI: 1914877 HomoloGene: 10613 GeneCards: OLFML3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene has also been associated with pectinate ligament dysplasia and glaucoma in Border Collies.[7]
References
- GRCh38: Ensembl release 89: ENSG00000116774 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000027848 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: OLFML3 olfactomedin-like 3".
- Miljkovic-Licina M, Hammel P, Garrido-Urbani S, Lee BP, Meguenani M, Chaabane C, et al. (December 2012). "Targeting olfactomedin-like 3 inhibits tumor growth by impairing angiogenesis and pericyte coverage". Molecular Cancer Therapeutics. 11 (12): 2588–2599. doi:10.1158/1535-7163.MCT-12-0245. PMID 23002094.
- Oliver JA, Wright H, Massidda PA, Burmeister LM, Mellersh CS (January 2020). "A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom". Veterinary Ophthalmology. 23 (1): 25–36. doi:10.1111/vop.12680. PMID 31141290. S2CID 169036374.
Further reading
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Zeng LC, Liu F, Zhang X, Zhu ZD, Wang ZQ, Han ZG, Ma WJ (July 2004). "hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis". FEBS Letters. 571 (1–3): 74–80. doi:10.1016/j.febslet.2004.06.059. PMID 15280020.
- Fautsch MP, Vrabel AM, Johnson DH (June 2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Experimental Eye Research. 82 (6): 1046–1052. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
- Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
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