OmcS oxidoreductase

OmcS nanowires (Geobacter nanowires) are conductive filaments found in some species of bacteria, including Geobacter sulfurreducens, where they catalyze the transfer of electrons. They are multiheme c-Type cytochromes localized outside of the cell of some exoelectrogenic bacterial species, serving as mediator of extracellular electron transfer from cells to Fe(III) oxides and other extracellular electron acceptors.[1]

OmcS (3D structure) has a core of six low-spin bis-histidinyl hexacoordinated heme groups inside a sinusoidal filament ~5-7.4 nm in diameter, with 46.7 Å rise per subunit and 4.3 subunits per turn. The six-heme packing motif of OmcS is identical to that seen in a ~3 nm diameter cytochrome nanowire, OmcE (3D structure), even though OmcE and OmcS share no sequence similarity.[2][3]

The OmcS gene can be one the most highly up-regulated genes in the Geobacter sulfurreducens KN400 strain when cultivated in a microbial fuel cell, as compared to the PCA strain, although a role for OmcS in electron transfer to electrodes has never been demonstrated.[4]

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