PACSIN3

PACSIN3
Identifiers
Aliases	PACSIN3, SDPIII, protein kinase C and casein kinase substrate in neurons 3
External IDs	OMIM: 606513 MGI: 1891410 HomoloGene: 41117 GeneCards: PACSIN3
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	47,186,443 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	91,095,024 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of tongue; ; left ventricle; ; left adrenal gland; ; sural nerve; ; triceps brachii muscle; ; minor salivary gland; ; right lobe of liver; ; body of stomach; ; left uterine tube;
	Top expressed in
	interventricular septum; ; temporal muscle; ; skeletal muscle tissue; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; esophagus; ; soleus muscle; ; lip; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; calcium channel inhibitor activity; protein binding; lipid binding; phospholipid binding;
Cellular component	endosome; plasma membrane; extracellular exosome; membrane; cytoplasm; cytosol; cytoskeleton;
Biological process	regulation of endocytosis; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; endocytosis; plasma membrane tubulation; negative regulation of calcium ion transport; regulation of molecular function; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	29763
	80708
	ENSG00000165912
	ENSMUSG00000027257
	Q9UKS6
	Q99JB8
	NM_016223; NM_001184974; NM_001184975
	NM_001289677; NM_001289678; NM_028733; NM_030880
	NP_001171903; NP_001171904; NP_057307
	NP_001276606; NP_001276607; NP_083009; NP_112019
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.[5][6]

Interactions

PACSIN3 has been shown to interact with PACSIN1[7] and PACSIN2.[7]

References

GRCh38: Ensembl release 89: ENSG00000165912 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027257 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Howard L, Nelson KK, Maciewicz RA, Blobel CP (December 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
"Entrez Gene: PACSIN3 protein kinase C and casein kinase substrate in neurons 3".
Modregger, J; Ritter B; Witter B; Paulsson M; Plomann M (December 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. ENGLAND. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. ISSN 0021-9533. PMID 11082044.

Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mori S, Tanaka M, Nanba D, et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor". J. Biol. Chem. 278 (46): 46029–34. doi:10.1074/jbc.M306393200. PMID 12952982.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMC 554134. PMID 15719014.
Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". J. Biol. Chem. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165912 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027257 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531379-5] Howard L, Nelson KK, Maciewicz RA, Blobel CP (December 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.

[entrez-6] "Entrez Gene: PACSIN3 protein kinase C and casein kinase substrate in neurons 3".

[pmid11082044-7] Modregger, J; Ritter B; Witter B; Paulsson M; Plomann M (December 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. ENGLAND. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. ISSN 0021-9533. PMID 11082044.

PACSIN3

Interactions

References

Further reading