PARD3

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.[5][6]

PARD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
External IDsOMIM: 606745 MGI: 2135608 HomoloGene: 10489 GeneCards: PARD3
Orthologs
SpeciesHumanMouse
Entrez

56288

93742

Ensembl

ENSG00000148498

ENSMUSG00000025812

UniProt

Q8TEW0

Q99NH2

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 34.11 – 34.82 MbChr 8: 127.79 – 128.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM][6]

Interactions

PARD3 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000148498 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025812 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
  6. "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".
  7. Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
  8. Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.
  9. Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.

Further reading


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