PCBP3

Poly(rC)-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene.[4][5]

PCBP3
Identifiers
AliasesPCBP3, ALPHA-CP3, poly(rC) binding protein 3
External IDsOMIM: 608502 MGI: 1890470 HomoloGene: 23233 GeneCards: PCBP3
Orthologs
SpeciesHumanMouse
Entrez

54039

59093

Ensembl

ENSG00000183570

ENSMUSG00000001120

UniProt

P57721

P57722

RefSeq (mRNA)

NM_020528
NM_001130141

NM_021568
NM_001347216

RefSeq (protein)

NP_001334145
NP_067543

Location (UCSC)n/aChr 10: 76.6 – 76.8 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene.[5]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000001120 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Makeyev AV, Liebhaber SA (Sep 2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics. 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID 10936052.
  5. "Entrez Gene: PCBP3 poly(rC) binding protein 3".

Further reading


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