PCDH8

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.[5][6][7]

PCDH8
Identifiers
AliasesPCDH8, ARCADLIN, PAPC, protocadherin 8
External IDsOMIM: 603580 MGI: 1306800 HomoloGene: 1943 GeneCards: PCDH8
Orthologs
SpeciesHumanMouse
Entrez

5100

18530

Ensembl

ENSG00000136099

ENSMUSG00000036422

UniProt

O95206

Q7TSK3

RefSeq (mRNA)

NM_032949
NM_002590

NM_001042726
NM_021543

RefSeq (protein)

NP_002581
NP_116567

NP_001036191
NP_067518

Location (UCSC)Chr 13: 52.84 – 52.85 MbChr 14: 80 – 80.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000136099 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036422 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics. 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079.
  6. Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol. 17 (10): 6157–66. doi:10.1128/MCB.17.10.6157. PMC 232466. PMID 9315676.
  7. "Entrez Gene: PCDH8 protocadherin 8".

Further reading


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