PCID2

PCID2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T5X
Identifiers
Aliases	PCID2, F10, PCI domain containing 2
External IDs	OMIM: 613713 MGI: 2443003 HomoloGene: 10168 GeneCards: PCID2
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	113,208,715 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	13,155,459 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; canal of the cervix; ; cerebellar hemisphere; ; left uterine tube; ; right coronary artery; ; right uterine tube; ; ascending aorta; ; anterior pituitary; ; body of pancreas;
	Top expressed in
	entorhinal cortex; ; otic placode; ; saccule; ; internal carotid artery; ; secondary oocyte; ; external carotid artery; ; spermatocyte; ; primitive streak; ; seminiferous tubule; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; double-stranded DNA binding; RNA binding;
Cellular component	nuclear pore; transcription export complex 2; cellular component; nucleus; cytoplasm; nuclear pore nuclear basket;
Biological process	positive regulation of B cell differentiation; positive regulation of transcription, DNA-templated; positive regulation of mitotic cell cycle spindle assembly checkpoint; negative regulation of apoptotic process; spleen development; regulation of mRNA stability; negative regulation of cysteine-type endopeptidase activity; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery; transcription elongation from RNA polymerase II promoter; poly(A)+ mRNA export from nucleus; protein transport; mRNA transport;
	Sources:Amigo / QuickGO
Orthologs
	55795
	234069
	ENSG00000126226
	ENSMUSG00000038542
	Q5JVF3
	Q8BFV2
NM_001127202; NM_001127203; NM_001258212; NM_001258213; NM_018386;
	NM_001320655; NM_001320656; NM_001320657; NM_001320659; NM_001320660; NM_001353091; NM_001353092; NM_001353093; NM_001353094; NM_001353095
	NM_178708
NP_001120674; NP_001120675; NP_001245142; NP_001307584; NP_001307585;
	NP_001307586; NP_001307588; NP_001307589; NP_060856; NP_001340020; NP_001340021; NP_001340022; NP_001340023; NP_001340024
	NP_848823
	Wikidata
View/Edit Human	View/Edit Mouse

PCI domain containing 2 is a protein that in humans is encoded by the PCID2 gene. [5]

Function

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

References

GRCh38: Ensembl release 89: ENSG00000126226 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038542 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PCI domain containing 2". Retrieved 2017-12-13.

Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z (2014). "Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability". Stem Cells. 32 (3): 623–35. doi:10.1002/stem.1580. PMID 24167073.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126226 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038542 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PCI domain containing 2". Retrieved 2017-12-13.

PCID2

Function

References

Further reading