PDCD4

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.[5][6] It is one of the targets of an oncomiR, MIRN21.[7]

PDCD4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
External IDsOMIM: 608610 MGI: 107490 HomoloGene: 7879 GeneCards: PDCD4
Orthologs
SpeciesHumanMouse
Entrez

27250

18569

Ensembl

ENSG00000150593

ENSMUSG00000024975

UniProt

Q53EL6

Q61823

RefSeq (mRNA)

NM_145341
NM_001199492
NM_014456

NM_001168491
NM_001168492
NM_011050

RefSeq (protein)

NP_001186421
NP_055271
NP_663314

NP_001161963
NP_001161964
NP_035180

Location (UCSC)Chr 10: 110.87 – 110.9 MbChr 19: 53.88 – 53.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.[6]

Interactions

PDCD4 has been shown to interact with RPS13,[8] ribosomal protein L5, [8] p62, LC3 and Ubiquitin [9]

References

  1. GRCh38: Ensembl release 89: ENSG00000150593 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024975 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of Immunology. 161 (7): 3493–500. PMID 9759869.
  6. EntrezGene 27250
  7. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
  8. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
9.  Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R,Takahashi H,  Anzai K, Matsuhashi S (2020). "Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy". Cells. 9(1): 218. doi.org/10.3390/cells9010218.

Further reading


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