PDE11A

PDE11A
Identifiers
Aliases	PDE11A, PPNAD2, phosphodiesterase 11A
External IDs	OMIM: 604961 MGI: 3036251 HomoloGene: 56763 GeneCards: PDE11A
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[1]
End	76,169,118 bp[1]
RNA expression pattern
	Top expressed in
	deltoid muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; liver; ; gastrocnemius muscle; ; prostate; ; biceps brachii; ; right lobe of liver; ; tibialis anterior muscle; ; tibia;
	Top expressed in
	hippocampus proper; ; ileum; ; midbrain tegmentum; ; jejunum; ; white adipose tissue; ; cerebellar cortex; ; superior frontal gyrus; ; spinal cord; ; retina; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; catalytic activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; cGMP binding;
Cellular component	cytoplasm; cytosol; cellular component;
Biological process	metabolism; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of cGMP-mediated signaling; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	50940
	241489
	n/a
	ENSMUSG00000075270
	Q9HCR9
	P0C1Q2
	NM_016953; NM_001077196; NM_001077197; NM_001077358
	NM_001081033
	NP_001070664; NP_001070665; NP_001070826; NP_058649
	NP_001074502
	Wikidata
View/Edit Human	View/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[4][5]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Inhibitors

BC11-38 [6]

References

GRCm38: Ensembl release 89: ENSMUSG00000075270 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
"Entrez Gene: PDE11A phosphodiesterase 11A".
Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362.

Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399–405. PMID 7935318.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Yuasa K, Kotera J, Fujishige K, et al. (2000). "Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression". J. Biol. Chem. 275 (40): 31469–79. doi:10.1074/jbc.M003041200. PMID 10906126.
Hetman JM, Robas N, Baxendale R, et al. (2001). "Cloning and characterization of two splice variants of human phosphodiesterase 11A". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12891–5. doi:10.1073/pnas.200355397. PMC 18860. PMID 11050148.
Yuasa K, Kanoh Y, Okumura K, Omori K (2001). "Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains". Eur. J. Biochem. 268 (1): 168–78. doi:10.1046/j.1432-1327.2001.01866.x. PMID 11121118.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants". Eur. J. Biochem. 268 (16): 4440–8. doi:10.1046/j.1432-1327.2001.02366.x. PMID 11502204.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Weeks JL, Zoraghi R, Beasley A, et al. (2005). "High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients". Int. J. Impot. Res. 17 (1): 5–9. doi:10.1038/sj.ijir.3901283. PMID 15538396.
Loughney K, Taylor J, Florio VA (2005). "3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320–5. doi:10.1038/sj.ijir.3901317. PMID 15800651.
Wayman C, Phillips S, Lunny C, et al. (2005). "Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology". Int. J. Impot. Res. 17 (3): 216–23. doi:10.1038/sj.ijir.3901307. PMID 15800654.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
D'Andrea MR, Qiu Y, Haynes-Johnson D, et al. (2005). "Expression of PDE11A in normal and malignant human tissues". J. Histochem. Cytochem. 53 (7): 895–903. doi:10.1369/jhc.5A6625.2005. PMID 15995148.
Francis SH (2005). "Phosphodiesterase 11 (PDE11): is it a player in human testicular function?". Int. J. Impot. Res. 17 (5): 467–8. doi:10.1038/sj.ijir.3901377. PMID 16079899.
Gross-Langenhoff M, Hofbauer K, Weber J, et al. (2006). "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11". J. Biol. Chem. 281 (5): 2841–6. doi:10.1074/jbc.M511468200. PMID 16330539.
Horvath A, Boikos S, Giatzakis C, et al. (2006). "A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia". Nat. Genet. 38 (7): 794–800. doi:10.1038/ng1809. PMID 16767104. S2CID 30482549.
Wong ML, Whelan F, Deloukas P, et al. (2006). "Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15124–9. Bibcode:2006PNAS..10315124W. doi:10.1073/pnas.0602795103. PMC 1581426. PMID 17008408.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000075270 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10725373-4] Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.

[entrez-5] "Entrez Gene: PDE11A phosphodiesterase 11A".

[pmid22284362-6] Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362.

PDE11A

Inhibitors

References

Further reading