PDE1A

PDE1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LXQ
Identifiers
Aliases	PDE1A, CAM-PDE-1A, HCAM-1, HCAM1, HSphosphodiesterase 1A, CAM-PDE 1A
External IDs	OMIM: 171890 MGI: 1201792 HomoloGene: 21043 GeneCards: PDE1A
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	182,523,359 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	79,959,802 bp[2]
RNA expression pattern
	Top expressed in
	sperm; ; Brodmann area 23; ; middle temporal gyrus; ; renal medulla; ; entorhinal cortex; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; cerebellar cortex; ; cerebellar hemisphere;
	Top expressed in
	spermatid; ; seminiferous tubule; ; superior frontal gyrus; ; subiculum; ; primary motor cortex; ; Region I of hippocampus proper; ; nucleus accumbens; ; spermatocyte; ; endocardial cushion; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; calmodulin binding; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytosol; cytoplasm; nucleus; neuronal cell body;
Biological process	cGMP catabolic process; cAMP catabolic process; signal transduction; regulation of smooth muscle cell apoptotic process; regulation of smooth muscle cell proliferation; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5136
	18573
	ENSG00000115252
	ENSMUSG00000059173
	P54750; Q9Y633
	Q61481
NM_001003683; NM_001258312; NM_001258313; NM_001258314; NM_005019;
	NM_001363871; NM_001395258; NM_001395259; NM_001395260; NM_001395261; NM_001395262; NM_001395263; NM_001395264; NM_001395265; NM_001395266; NM_001395267; NM_001395268; NM_001395269
NM_001009978; NM_001009979; NM_001159582; NM_016744; NM_001355140;
	NM_001355141; NM_001355142; NM_001355143; NM_001355144
NP_001003683; NP_001245241; NP_001245242; NP_001245243; NP_005010;
	NP_001350800; NP_001245241.1
NP_001009978; NP_001009979; NP_001153054; NP_058024; NP_001342069;
	NP_001342070; NP_001342071; NP_001342073
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000115252 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059173 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.
Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.
"Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Snyder PB, Florio VA, Ferguson K, Loughney K (1999). "Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A)". Cell. Signal. 11 (7): 535–44. doi:10.1016/S0898-6568(99)00027-3. PMID 10405764.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.
Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
Ritter M, Buechler C, Boettcher A, et al. (2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I". Genomics. 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.
Lefièvre L, de Lamirande E, Gagnon C (2003). "Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa". Biol. Reprod. 67 (2): 423–30. doi:10.1095/biolreprod67.2.423. PMID 12135876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Goraya TA, Masada N, Ciruela A, Cooper DM (2004). "Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A". J. Biol. Chem. 279 (39): 40494–504. doi:10.1074/jbc.M313441200. PMID 15272012.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nagel DJ, Aizawa T, Jeon KI, et al. (2006). "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival". Circ. Res. 98 (6): 777–84. doi:10.1161/01.RES.0000215576.27615.fd. PMC 4114760. PMID 16514069.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115252 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059173 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8557689-5] Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.

[pmid11342109-6] Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.

[entrez-7] "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent".

PDE1A

References

Further reading