PDE1B

PDE1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TAZ, 4NPV, 4NPW, 5B25
Identifiers
Aliases	PDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B
External IDs	OMIM: 171891 MGI: 97523 HomoloGene: 37370 GeneCards: PDE1B
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	54,579,239 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	103,438,479 bp[2]
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; gastric mucosa; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; ascending aorta; ; middle frontal gyrus; ; subcutaneous adipose tissue;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; superior frontal gyrus; ; globus pallidus; ; entorhinal cortex; ; superior colliculus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; inferior colliculus; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; calmodulin binding; cyclic-nucleotide phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; protein binding; phosphoric diester hydrolase activity; hydrolase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytoplasm; neuronal cell body; cytosol;
Biological process	visual learning; regulation of neurotransmitter levels; cAMP catabolic process; locomotory behavior; response to amphetamine; serotonin metabolic process; monocyte differentiation; regulation of dopamine metabolic process; cellular response to macrophage colony-stimulating factor stimulus; cGMP catabolic process; cellular response to granulocyte macrophage colony-stimulating factor stimulus; apoptotic process; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5153
	18574
	ENSG00000123360
	ENSMUSG00000022489
	Q01064
	Q01065
NM_000924; NM_001165975; NM_001288768; NM_001288769; NM_001315534;
	NM_001315535
	NM_001285890; NM_008800; NM_001357980
NP_000915; NP_001159447; NP_001275697; NP_001275698; NP_001302463;
	NP_001302464
	NP_001272819; NP_032826; NP_001344909
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000123360 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022489 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.
Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.
"Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase". J. Biol. Chem. 267 (26): 18683–8. doi:10.1016/S0021-9258(19)37015-2. PMID 1326532.
Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase". Biochem. J. 321 ( Pt 1) (Pt 1): 157–63. doi:10.1042/bj3210157. PMC 1218050. PMID 9003415.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. Bibcode:2005PNAS..102..497B. doi:10.1073/pnas.0408535102. PMC 544304. PMID 15625104.
Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. Bibcode:2006PNAS..103..460B. doi:10.1073/pnas.0509972102. PMC 1326187. PMID 16407168.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123360 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022489 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8855339-5] Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.

[pmid9419816-6] Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.

[entrez-7] "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

PDE1B

References

Further reading