PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.[5][6][7] PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC 3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.[8]

PDE6D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE6D, JBTS22, PDED, phosphodiesterase 6D
External IDsOMIM: 602676 MGI: 1270843 HomoloGene: 1954 GeneCards: PDE6D
EC number3.1.4.35
Orthologs
SpeciesHumanMouse
Entrez

5147

18582

Ensembl

ENSG00000156973

ENSMUSG00000026239

UniProt

O43924
Q6IB24

O55057

RefSeq (mRNA)

NM_001291018
NM_002601

NM_008801
NM_001360816
NM_001360817

RefSeq (protein)

NP_001277947
NP_002592
NP_002592.1

NP_032827
NP_001347745
NP_001347746

Location (UCSC)Chr 2: 231.73 – 231.79 MbChr 1: 86.47 – 86.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PDE6D has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000156973 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026239 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ershova G, Derré J, Chételin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J (Apr 1998). "cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36". Cytogenetics and Cell Genetics. 79 (1–2): 139–41. doi:10.1159/000134701. PMID 9533031.
  6. Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W (Apr 1998). "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene". Genomics. 49 (1): 76–82. doi:10.1006/geno.1998.5210. PMID 9570951.
  7. "Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta".
  8. Wittinghofer A, Renault L, Hanzal-bayer M, Roversi P, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–2106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  10. Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  11. Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
  12. Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1315–20. Bibcode:1999PNAS...96.1315L. doi:10.1073/pnas.96.4.1315. PMC 15460. PMID 9990021.

Further reading

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