PDE6G

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.[5][6][7]

PDE6G
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE6G, PDEG, RP57, phosphodiesterase 6G
External IDsOMIM: 180073 MGI: 97526 HomoloGene: 1955 GeneCards: PDE6G
Orthologs
SpeciesHumanMouse
Entrez

5148

18588

Ensembl

ENSG00000185527

ENSMUSG00000025386

UniProt

P18545

P09174

RefSeq (mRNA)

NM_002602
NM_001365724
NM_001365725

NM_012065

RefSeq (protein)

NP_002593
NP_001352653
NP_001352654

NP_036197

Location (UCSC)Chr 17: 81.65 – 81.66 MbChr 11: 120.34 – 120.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase[8] and Src.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000185527 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025386 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (February 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
  6. "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
  7. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L (February 2019). "Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 5 (2): eaav4322. Bibcode:2019SciA....5.4322G. doi:10.1126/sciadv.aav4322. PMC 6392808. PMID 30820458.
  8. Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". The Journal of Biological Chemistry. 278 (20): 18658–63. doi:10.1074/jbc.M212103200. PMID 12624098. S2CID 25824189.

Further reading

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