PDLIM5

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.[5][6]

PDLIM5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDLIM5, ENH, ENH1, LIM, L9, PDZ and LIM domain 5
External IDsOMIM: 605904 MGI: 1927489 HomoloGene: 21289 GeneCards: PDLIM5
Orthologs
SpeciesHumanMouse
Entrez

10611

56376

Ensembl

ENSG00000163110

ENSMUSG00000028273

UniProt

Q96HC4

Q8CI51

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 94.45 – 94.67 MbChr 3: 141.95 – 142.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N-terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.[6]

Interactions

PDLIM5 has been shown to interact with PRKCB1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000163110 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028273 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq. 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770. S2CID 36916587.
  6. "Entrez Gene: PDLIM5 PDZ and LIM domain 5".
  7. Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095.

Further reading

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