PERP

p53 apoptosis effector related to PMP-22 is a plasma membrane protein that, in humans, is encoded by the PERP gene.[5][6]

PERP
Identifiers
AliasesPERP, KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1, TP53 apoptosis effector, p53 apoptosis effector related to PMP22, EKVP7, OLMS2
External IDsOMIM: 609301 MGI: 1929938 HomoloGene: 11098 GeneCards: PERP
Orthologs
SpeciesHumanMouse
Entrez

64065

64058

Ensembl

ENSG00000112378

ENSMUSG00000019851

UniProt

Q96FX8

Q9JK95

RefSeq (mRNA)

NM_022121

NM_022032

RefSeq (protein)

NP_071404

NP_071315

Location (UCSC)Chr 6: 138.09 – 138.11 MbChr 10: 18.72 – 18.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PERP is a direct transcriptional target of p53, but its transcription can also be regulated by other transcription factors.[7]

PERP is important for skin development, and loss of PERP is associated with the development and progression of several types of human cancers.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000112378 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019851 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res. 20 (5A): 2801–2809. PMID 11062687.
  6. "Entrez Gene: PERP PERP, TP53 apoptosis effector".
  7. Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP". Biochim Biophys Acta Rev Cancer. 1874 (1): 188393. doi:10.1016/j.bbcan.2020.188393. PMID 32679166. S2CID 220631324.

Further reading

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