PES1

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.[5][6][7][8]

PES1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7
External IDsOMIM: 605819 MGI: 1890613 HomoloGene: 5984 GeneCards: PES1
Orthologs
SpeciesHumanMouse
Entrez

23481

64934

Ensembl

ENSG00000100029

ENSMUSG00000020430

UniProt

O00541

Q9EQ61

RefSeq (mRNA)

NM_001243225
NM_001282327
NM_001282328
NM_014303

NM_022889

RefSeq (protein)

NP_001230154
NP_001269256
NP_001269257
NP_055118

NP_075027

Location (UCSC)Chr 22: 30.58 – 30.61 MbChr 11: 3.91 – 3.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000100029 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020430 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N (Jan 1997). "Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development". Genes Dev. 10 (24): 3141–55. doi:10.1101/gad.10.24.3141. PMID 8985183.
  6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  7. Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 Controls Nucleolar Localization and Assembly of the PeBoW Complex Required for Maturation of the 60S Ribosomal Subunit". Mol Cell Biol. 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269.
  8. "Entrez Gene: PES1 pescadillo homolog 1, containing BRCT domain (zebrafish)".

Further reading

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