PFDN1

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.[5][6]

PFDN1
Identifiers
AliasesPFDN1, PDF, PFD1, prefoldin subunit 1
External IDsOMIM: 604897 MGI: 1914449 HomoloGene: 37644 GeneCards: PFDN1
Orthologs
SpeciesHumanMouse
Entrez

5201

67199

Ensembl

ENSG00000113068

ENSMUSG00000024346

UniProt

O60925

Q9CWM4
Q9CQF7

RefSeq (mRNA)

NM_002622

NM_026027

RefSeq (protein)

NP_002613

NP_080303

Location (UCSC)Chr 5: 140.25 – 140.3 MbChr 18: 36.54 – 36.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000113068 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024346 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
  6. "Entrez Gene: PFDN1 prefoldin subunit 1".

Further reading

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