PFDN1

PFDN1
Identifiers
Aliases	PFDN1, PDF, PFD1, prefoldin subunit 1
External IDs	OMIM: 604897 MGI: 1914449 HomoloGene: 37644 GeneCards: PFDN1
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	140,303,113 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	36,587,577 bp[2]
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; islet of Langerhans; ; prefrontal cortex; ; cingulate gyrus; ; left ventricle; ; Brodmann area 9; ; amygdala; ; smooth muscle tissue; ; nucleus accumbens;
	Top expressed in
	ventromedial nucleus; ; mammillary body; ; lateral hypothalamus; ; facial motor nucleus; ; external carotid artery; ; maxillary prominence; ; lateral geniculate nucleus; ; arcuate nucleus; ; internal carotid artery; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; unfolded protein binding; protein folding chaperone activity;
Cellular component	prefoldin complex; cytoplasm;
Biological process	regulation of transcription, DNA-templated; protein folding; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	5201
	67199
	ENSG00000113068
	ENSMUSG00000024346
	O60925
	Q9CWM4; Q9CQF7
	NM_002622
	NM_026027
	NP_002613
	NP_080303
	Wikidata
View/Edit Human	View/Edit Mouse

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.[5][6]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[6]

References

GRCh38: Ensembl release 89: ENSG00000113068 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024346 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
"Entrez Gene: PFDN1 prefoldin subunit 1".

Hartl FU, Hayer-Hartl M (2002). "Molecular chaperones in the cytosol: from nascent chain to folded protein". Science. 295 (5561): 1852–8. doi:10.1126/science.1068408. PMID 11884745. S2CID 15037639.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Iijima M, Kano Y, Nohno T, Namba M (1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Med. Okayama. 50 (2): 73–7. PMID 8744932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Horrigan SK, Bartoloni L, Speer MC, et al. (1999). "A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences". Genomics. 57 (1): 24–35. doi:10.1006/geno.1999.5765. PMID 10191080.
Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins". J. Cell Biol. 145 (2): 265–77. doi:10.1083/jcb.145.2.265. PMC 2133115. PMID 10209023.
Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082. S2CID 22081346.
Munnia A, Schütz N, Romeike BF, et al. (2001). "Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor". Oncogene. 20 (35): 4853–63. doi:10.1038/sj.onc.1204650. PMID 11521196.
Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601.
Martín-Benito J, Boskovic J, Gómez-Puertas P, et al. (2003). "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT". EMBO J. 21 (23): 6377–86. doi:10.1093/emboj/cdf640. PMC 136944. PMID 12456645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bruneel A, Labas V, Mailloux A, et al. (2004). "Proteomic study of human umbilical vein endothelial cells in culture". Proteomics. 3 (5): 714–23. doi:10.1002/pmic.200300409. PMID 12748950. S2CID 19895166.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113068 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024346 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9630229-5] Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.

[entrez-6] "Entrez Gene: PFDN1 prefoldin subunit 1".

PFDN1

References

Further reading