PHLPP (gene)

PHLPP1
Identifiers
Aliases	PHLPP1, PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1
External IDs	OMIM: 609396 MGI: 2138327 HomoloGene: 11015 GeneCards: PHLPP1
Gene location (Human)
Chr.	Chromosome 18 (human)[1]
End	62,980,433 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	106,321,980 bp[2]
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; middle frontal gyrus; ; inferior ganglion of vagus nerve; ; optic nerve; ; ganglionic eminence; ; Region I of hippocampus proper; ; external globus pallidus; ; subthalamic nucleus; ; Brodmann area 10;
	Top expressed in
	lateral geniculate nucleus; ; globus pallidus; ; substantia nigra; ; medial geniculate nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; medial dorsal nucleus; ; mammillary body; ; superior colliculus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; metal ion binding; protein binding; catalytic activity; hydrolase activity; protein serine/threonine phosphatase activity;
Cellular component	cytosol; membrane; nucleus; cytoplasm; plasma membrane; nuclear membrane; photoreceptor inner segment; photoreceptor outer segment membrane;
Biological process	regulation of apoptotic process; regulation of MAPK cascade; protein dephosphorylation; entrainment of circadian clock; regulation of JNK cascade; regulation of T cell anergy; regulation of p38MAPK cascade; apoptotic process; regulation of protein kinase C signaling; negative regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	23239
	98432
	ENSG00000081913
	ENSMUSG00000044340
	O60346
	Q8CHE4
	NM_194449
	NM_133821
	NP_919431
	NP_598582
	Wikidata
View/Edit Human	View/Edit Mouse

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000081913 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000044340 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus". FEBS Lett. 458 (3): 363–9. doi:10.1016/S0014-5793(99)01190-4. PMID 10570941. S2CID 38044717.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth". Mol. Cell. 18 (1): 13–24. doi:10.1016/j.molcel.2005.03.008. PMID 15808505.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. doi:10.1038/nature03983. PMID 16177791.
Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081913 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044340 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

PHLPP (gene)

See also

References

Further reading