PIGB

PIGB
Identifiers
Aliases	PIGB, GPI-MT-III, PIG-B, phosphatidylinositol glycan anchor biosynthesis class B, EIEE80, DEE80
External IDs	OMIM: 604122 MGI: 1891825 HomoloGene: 3570 GeneCards: PIGB
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	55,355,648 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	72,947,660 bp[2]
RNA expression pattern
	Top expressed in
	blood; ; Achilles tendon; ; monocyte; ; anterior pituitary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; gastric mucosa; ; spleen; ; right uterine tube;
	Top expressed in
	ascending aorta; ; aortic valve; ; supraoptic nucleus; ; superior frontal gyrus; ; morula; ; proximal tubule; ; secondary oocyte; ; lip; ; yolk sac; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; mannosyltransferase activity; glycosyltransferase activity; glycolipid mannosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; mannosylation;
	Sources:Amigo / QuickGO
Orthologs
	9488
	55981
	ENSG00000069943
	ENSMUSG00000079469
	Q92521
	Q9JJQ0
	NM_004855
	NM_018889
	NP_004846
	NP_061377
	Wikidata
View/Edit Human	View/Edit Mouse

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.[5][6]

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.[6]

References

GRCh38: Ensembl release 89: ENSG00000069943 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079469 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Takahashi M, Inoue N, Ohishi K, Maeda Y, Nakamura N, Endo Y, Fujita T, Takeda J, Kinoshita T (Dec 1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor". EMBO J. 15 (16): 4254–61. doi:10.1002/j.1460-2075.1996.tb00800.x. PMC 452151. PMID 8861954.
"Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B".

Mohney RP, Knez JJ, Ravi L, et al. (1994). "Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants". J. Biol. Chem. 269 (9): 6536–42. doi:10.1016/S0021-9258(17)37405-7. PMID 7907094.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Anikster Y, Huizing M, Anderson PD, et al. (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A". Am. J. Hum. Genet. 71 (2): 407–14. doi:10.1086/341606. PMC 379173. PMID 12058346.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069943 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079469 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8861954-5] Takahashi M, Inoue N, Ohishi K, Maeda Y, Nakamura N, Endo Y, Fujita T, Takeda J, Kinoshita T (Dec 1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor". EMBO J. 15 (16): 4254–61. doi:10.1002/j.1460-2075.1996.tb00800.x. PMC 452151. PMID 8861954.

[entrez-6] "Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B".

PIGB

References

Further reading