PIGS (gene)

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene.[5] This gene encodes a protein that is involved in GPI-anchor biosynthesis.

PIGS
Identifiers
AliasesPIGS, phosphatidylinositol glycan anchor biosynthesis class S, GPIBD18, DEE95
External IDsOMIM: 610271 MGI: 2687325 HomoloGene: 41963 GeneCards: PIGS
Orthologs
SpeciesHumanMouse
Entrez

94005

276846

Ensembl

ENSG00000087111

ENSMUSG00000041958

UniProt

Q96S52

Q6PD26

RefSeq (mRNA)

NM_033198

NM_201406

RefSeq (protein)

NP_149975

NP_958808

Location (UCSC)Chr 17: 28.55 – 28.57 MbChr 11: 78.22 – 78.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000087111 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041958 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PIGS phosphatidylinositol glycan anchor biosynthesis, class S".

Further reading


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