PIK3AP1

PIK3AP1
Identifiers
Aliases	PIK3AP1, BCAP, phosphoinositide-3-kinase adaptor protein 1
External IDs	OMIM: 607942 MGI: 1933177 HomoloGene: 12848 GeneCards: PIK3AP1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	96,720,514 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	41,373,541 bp[2]
RNA expression pattern
	Top expressed in
	parotid gland; ; pancreatic epithelial cell; ; monocyte; ; pancreatic ductal cell; ; appendix; ; blood; ; cancellous bone; ; bone marrow; ; liver; ; bone marrow cells;
	Top expressed in
	submandibular gland; ; spleen; ; blood; ; Paneth cell; ; liver; ; right lung lobe; ; lymph node; ; carotid body; ; conjunctival fornix; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol 3-kinase regulatory subunit binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; signaling receptor binding;
Cellular component	cytoplasm; cytosol; plasma membrane; membrane;
Biological process	positive regulation of phosphatidylinositol 3-kinase signaling; toll-like receptor 9 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; regulation of inflammatory response; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	118788
	83490
	ENSG00000155629
	ENSMUSG00000025017
	Q6ZUJ8
	Q9EQ32
	NM_152309
	NM_031376
	NP_689522
	NP_113553
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000155629 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025017 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med. 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity. 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.
"Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Maruoka M, Suzuki J, Kawata S, et al. (2005). "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases". FEBS Lett. 579 (14): 2986–90. doi:10.1016/j.febslet.2005.04.052. PMID 15893754. S2CID 20802390.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155629 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025017 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1251844-5] Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med. 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.

[pmid11163197-6] Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity. 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.

[entrez-7] "Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

PIK3AP1

References

Further reading