PKIB

cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene.[5][6]

PKIB
Identifiers
AliasesPKIB, PRKACN2, protein kinase (cAMP-dependent, catalytic) inhibitor beta, cAMP-dependent protein kinase inhibitor beta
External IDsOMIM: 606914 MGI: 101937 HomoloGene: 7474 GeneCards: PKIB
Orthologs
SpeciesHumanMouse
Entrez

5570

18768

Ensembl

ENSG00000135549

ENSMUSG00000019876

UniProt

Q9C010

Q04758

RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr 6: 122.47 – 122.73 MbChr 10: 57.51 – 57.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000135549 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019876 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
  6. "Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta".

Further reading


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