PKIB

PKIB
Identifiers
Aliases	PKIB, PRKACN2, protein kinase (cAMP-dependent, catalytic) inhibitor beta, cAMP-dependent protein kinase inhibitor beta
External IDs	OMIM: 606914 MGI: 101937 HomoloGene: 7474 GeneCards: PKIB
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	122,726,373 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	57,617,208 bp[2]
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; rectum; ; placenta; ; bronchial epithelial cell; ; pons; ; islet of Langerhans; ; jejunal mucosa; ; pituitary gland; ; anterior pituitary;
	Top expressed in
	seminiferous tubule; ; spermatid; ; olfactory epithelium; ; cerebellar vermis; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; carotid body; ; pontine nuclei; ; paraventricular nucleus of hypothalamus; ; piriform cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase inhibitor activity; cAMP-dependent protein kinase inhibitor activity;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of telomere maintenance via telomerase; positive regulation of telomere capping; positive regulation of telomerase activity; negative regulation of cAMP-dependent protein kinase activity; negative regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5570
	18768
	ENSG00000135549
	ENSMUSG00000019876
	Q9C010
	Q04758
NM_001270393; NM_001270394; NM_001270395; NM_032471; NM_181794;
	NM_181795
NM_001039050; NM_001039051; NM_001039052; NM_001039053; NM_001190402;
	NM_008863
NP_001257322; NP_001257323; NP_001257324; NP_115860; NP_861459;
	NP_861460
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene.[5][6]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

GRCh38: Ensembl release 89: ENSG00000135549 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019876 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
"Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Giangrande PH, Hallstrom TC, Tunyaplin C, et al. (2003). "Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor". Mol. Cell. Biol. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231. PMID 12748276.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Qi ZY, Li Y, Ying K, et al. (2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes". J. Neurooncol. 56 (3): 197–208. doi:10.1023/A:1015079705841. PMID 12061725. S2CID 23878825.
Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
Scarpetta MA, Uhler MD (1993). "Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse". J. Biol. Chem. 268 (15): 10927–31. doi:10.1016/S0021-9258(18)82074-9. PMID 7684369.
Van Patten SM, Ng DC, Th'ng JP, et al. (1991). "Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5383–7. doi:10.1073/pnas.88.12.5383. PMC 51877. PMID 2052616.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135549 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019876 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10880337-5] Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.

[entrez-6] "Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta".

PKIB

References

Further reading