PLA2G5

Calcium-dependent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G5 gene.[5][6][7]

PLA2G5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLA2G5, FRFB, GV-PLA2, PLA2-10, hVPLA(2), phospholipase A2 group V
External IDsOMIM: 601192 MGI: 101899 HomoloGene: 716 GeneCards: PLA2G5
Orthologs
SpeciesHumanMouse
Entrez

5322

18784

Ensembl

ENSG00000127472

ENSMUSG00000041193

UniProt

P39877

P97391

RefSeq (mRNA)

NM_000929

NM_001122954
NM_011110

RefSeq (protein)

NP_000920

NP_001116426
NP_035240

Location (UCSC)Chr 1: 20.03 – 20.09 MbChr 4: 138.53 – 138.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]

[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000127472 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041193 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ (February 1997). "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human". Genomics. 32 (3): 328–33. doi:10.1006/geno.1996.0126. PMID 8838795.
  6. Chen J, Engle SJ, Seilhamer JJ, Tischfield JA (March 1994). "Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2". J Biol Chem. 269 (4): 2365–8. doi:10.1016/S0021-9258(17)41952-1. PMID 8300559.
  7. "Entrez Gene: PLA2G5 phospholipase A2, group V".
  8. Otha, Shin (15 June 2013). "Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation". Journal of Immunology. 12 (190): 5927–38. doi:10.4049/jimmunol.1203202. PMC 3939699. PMID 23650617.

Further reading

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