PLAGL2

PLAGL2
Identifiers
Aliases	PLAGL2, ZNF900, PLAG1 like zinc finger 2
External IDs	OMIM: 604866 MGI: 1933165 HomoloGene: 1994 GeneCards: PLAGL2
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	32,207,743 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	153,083,346 bp[2]
RNA expression pattern
	Top expressed in
	sperm; ; monocyte; ; secondary oocyte; ; amniotic fluid; ; pancreatic ductal cell; ; bone marrow cells; ; ganglionic eminence; ; rectum; ; blood; ; body of stomach;
	Top expressed in
	mirror; ; maxillary prominence; ; ileum; ; inner renal medulla; ; endocardial cushion; ; somite; ; external carotid artery; ; ureter; ; hand; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; DNA binding; nucleic acid binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; chylomicron assembly; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; lipid metabolism; positive regulation of intrinsic apoptotic signaling pathway; post-embryonic development; transcription by RNA polymerase II; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5326
	54711
	ENSG00000126003
	ENSMUSG00000051413
	Q9UPG8
	Q925T4
	NM_002657
	NM_018807
	NP_002648
	NP_061277
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.[5][6][7]

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.[7]

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.[8]

References

GRCh38: Ensembl release 89: ENSG00000126003 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000051413 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.
Zheng G, Ning J, Yang YC (Oct 2007). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53". Biochem Biophys Res Commun. 364 (2): 344–50. doi:10.1016/j.bbrc.2007.10.003. PMC 2708094. PMID 17950244.
"Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2".
Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010). "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497–509. doi:10.1016/j.ccr.2010.03.020. PMC 2900858. PMID 20478531.

Guo Y, Yang MC, Weissler JC, Yang YS (2007). "PLAGL2 Translocation and SP-C Promoter Activity – A Cellular Response of Lung Cells to Hypoxia". Biochem. Biophys. Res. Commun. 360 (3): 659–65. doi:10.1016/j.bbrc.2007.06.106. PMC 2084061. PMID 17618602.
Ammons MC, Siemsen DW, Nelson-Overton LK, et al. (2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity". J. Biol. Chem. 282 (24): 17941–52. doi:10.1074/jbc.M610618200. PMID 17462995.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yang MC, Weissler JC, Terada LS, et al. (2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. Respir. Cell Mol. Biol. 32 (1): 35–43. CiteSeerX 10.1.1.325.6715. doi:10.1165/rcmb.2003-0422OC. PMID 15361364.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Furukawa T, Adachi Y, Fujisawa J, et al. (2001). "Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines". Oncogene. 20 (34): 4718–27. doi:10.1038/sj.onc.1204647. PMID 11498794.
Kas K, Voz ML, Hensen K, et al. (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126003 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051413 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15585652-5] Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.

[pmid17950244-6] Zheng G, Ning J, Yang YC (Oct 2007). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53". Biochem Biophys Res Commun. 364 (2): 344–50. doi:10.1016/j.bbrc.2007.10.003. PMC 2708094. PMID 17950244.

[entrez-7] "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2".

[pmid20478531-8] Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010). "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497–509. doi:10.1016/j.ccr.2010.03.020. PMC 2900858. PMID 20478531.

PLAGL2

References

Further reading