PLEKHO1

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.[5][6]

PLEKHO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLEKHO1, CKIP-1, OC120, CKIP1, JBP, pleckstrin homology domain containing O1
External IDsOMIM: 608335 MGI: 1914470 HomoloGene: 9448 GeneCards: PLEKHO1
Orthologs
SpeciesHumanMouse
Entrez

51177

67220

Ensembl

ENSG00000023902

ENSMUSG00000015745

UniProt

Q53GL0

Q9JIY0

RefSeq (mRNA)

NM_016274
NM_001304722
NM_001304723
NM_001304724

NM_023320

RefSeq (protein)

NP_001291651
NP_001291652
NP_001291653
NP_057358

NP_075809

Location (UCSC)Chr 1: 150.15 – 150.16 MbChr 3: 95.9 – 95.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1[5] and SMURF1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000023902 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015745 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW (May 2000). "Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2". The Journal of Biological Chemistry. 275 (19): 14295–306. doi:10.1074/jbc.275.19.14295. PMID 10799509.
  6. "Entrez Gene: PLEKHO1 pleckstrin homology domain containing, family O member 1".
  7. Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F (August 2008). "Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1". Nature Cell Biology. 10 (8): 994–1002. doi:10.1038/ncb1760. PMID 18641638. S2CID 19216909.

Further reading

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