POLDIP3

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.[5][6]

POLDIP3
Identifiers
AliasesPOLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDsOMIM: 611520 MGI: 1921076 HomoloGene: 13007 GeneCards: POLDIP3
Orthologs
SpeciesHumanMouse
Entrez

84271

73826

Ensembl

ENSG00000100227

ENSMUSG00000041815

UniProt

Q9BY77
Q8WUT1

Q8BG81

RefSeq (mRNA)

NM_001278657
NM_032311
NM_178136
NM_001363052

NM_178627
NM_001347082

RefSeq (protein)

NP_001265586
NP_115687
NP_835237
NP_001349981

NP_001334011
NP_848742

Location (UCSC)Chr 22: 42.58 – 42.61 MbChr 15: 83.01 – 83.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[6]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000100227 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041815 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
  6. "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
  7. Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. England. 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.