POLR2F

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.[5]

POLR2F
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2F, HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F, RNA polymerase II subunit F, RNA polymerase II, I and III subunit F
External IDsOMIM: 604414 MGI: 1349393 HomoloGene: 7178 GeneCards: POLR2F
Orthologs
SpeciesHumanMouse
Entrez

5435

69833

Ensembl

ENSG00000100142

ENSMUSG00000033020

UniProt

P61218

P61219

RefSeq (mRNA)

NM_001301129
NM_001301130
NM_001301131
NM_021974
NM_001363825

NM_027231

RefSeq (protein)

NP_001288058
NP_001288059
NP_001288060
NP_068809
NP_001350754

NP_081507

Location (UCSC)Chr 22: 37.95 – 38.04 MbChr 15: 79.03 – 79.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.[6]

Interactions

POLR2F has been shown to interact with POLR2C.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000100142 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033020 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pusch C, Wang Z, Roe B, Blin N (September 1996). "Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity". Genomics. 34 (3): 440–2. doi:10.1006/geno.1996.0312. PMID 8786150.
  6. "Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F".
  7. Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

Further reading

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