POLR2H

DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

POLR2H
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2H, RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H
External IDsOMIM: 606023 MGI: 2384309 HomoloGene: 4540 GeneCards: POLR2H
Orthologs
SpeciesHumanMouse
Entrez

5437

245841

Ensembl

ENSG00000163882

ENSMUSG00000021018

UniProt

P52434

Q923G2

RefSeq (mRNA)

NM_145632
NM_001356423

RefSeq (protein)

NP_663607
NP_001343352

Location (UCSC)Chr 3: 184.36 – 184.37 MbChr 16: 20.54 – 20.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.[5]

Interactions

POLR2H has been shown to interact with POLR2C,[6] POLR2G,[6] POLR2A,[6] POLR2B[6] and POLR2E.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000163882 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021018 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: POLR2H polymerase (RNA) II (DNA directed) polypeptide H".
  6. Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

Further reading

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