POLR2I

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.[5]

POLR2I
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2I, RPB9, hRPB14.5, polymerase (RNA) II subunit I, RNA polymerase II subunit I
External IDsOMIM: 180662 MGI: 1917170 HomoloGene: 4541 GeneCards: POLR2I
Orthologs
SpeciesHumanMouse
Entrez

5438

69920

Ensembl

ENSG00000105258

ENSMUSG00000019738

UniProt

P36954

P60898

RefSeq (mRNA)

NM_006233

NM_027259

RefSeq (protein)

NP_006224

NP_081535

Location (UCSC)Chr 19: 36.11 – 36.12 MbChr 7: 29.93 – 29.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000105258 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019738 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
  6. "Entrez Gene: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa".

Further reading

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