POLR2J2

POLR2J2
Identifiers
Aliases	POLR2J2, polymerase (RNA) II (DNA directed) polypeptide J2, HRPB11B, RPB11b1, polymerase (RNA) II subunit J2, RNA polymerase II subunit J2, RPB11b2, POLR2J3
External IDs	OMIM: 609881 HomoloGene: 129653 GeneCards: POLR2J2
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	102,671,629 bp[1]
RNA expression pattern
	Top expressed in
	blood; ; stromal cell of endometrium; ; sural nerve; ; monocyte; ; bone marrow cells; ; spleen; ; gastric mucosa; ; Achilles tendon; ; duodenum; ; right lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; DNA binding; protein dimerization activity; RNA polymerase II activity;
Cellular component	nucleus; RNA polymerase II, core complex;
Biological process	transcription, DNA-templated; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	246721
	n/a
	ENSG00000228049
	n/a
	Q9GZM3
	n/a
	NM_145325; NM_032958; NM_032959
	n/a
	NP_001091084; NP_116581
	n/a
	Wikidata
View/Edit Human

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.[3]

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.[3]

References

GRCh38: Ensembl release 89: ENSG00000228049 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene".

Shpakovskii DG, Shematorova EK, Shpakovskii GV (2006). "Human PMS2 gene family: origin, molecular evolution, and biological implications". Dokl. Biochem. Biophys. 408: 175–179. doi:10.1134/S1607672906030185. PMID 16913423. S2CID 30897463.
Benga WJ, Grandemange S, Shpakovski GV, et al. (2005). "Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II". Nucleic Acids Res. 33 (11): 3582–3590. doi:10.1093/nar/gki672. PMC 1159119. PMID 15987790.
Shpakovskiĭ DG, Shematorova EK, Shpakovskiĭ GV (2005). "[New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]". Bioorg. Khim. 30 (6): 621–5. doi:10.1023/b:rubi.0000049773.14555.4c. PMID 15586814. S2CID 1452697.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Durrin LK, Krontiris TG (2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics. 79 (6): 809–817. doi:10.1006/geno.2002.6772. PMID 12036295.
Grandemange S, Schaller S, Yamano S, et al. (2003). "A human RNA polymerase II subunit is encoded by a recently generated multigene family". BMC Mol. Biol. 2: 14. doi:10.1186/1471-2199-2-14. PMC 61041. PMID 11747469.
Cramer P, Bushnell DA, Fu J, et al. (2000). "Architecture of RNA polymerase II and implications for the transcription mechanism". Science. 288 (5466): 640–649. Bibcode:2000Sci...288..640C. doi:10.1126/science.288.5466.640. hdl:11858/00-001M-0000-0015-872F-3. PMID 10784442.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000228049 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene".

POLR2J2

References

Further reading