POLR2J2

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.[3]

POLR2J2
Identifiers
AliasesPOLR2J2, polymerase (RNA) II (DNA directed) polypeptide J2, HRPB11B, RPB11b1, polymerase (RNA) II subunit J2, RNA polymerase II subunit J2, RPB11b2, POLR2J3
External IDsOMIM: 609881 HomoloGene: 129653 GeneCards: POLR2J2
Orthologs
SpeciesHumanMouse
Entrez

246721

n/a

Ensembl

ENSG00000228049

n/a

UniProt

Q9GZM3

n/a

RefSeq (mRNA)

NM_145325
NM_032958
NM_032959

n/a

RefSeq (protein)

NP_001091084
NP_116581

n/a

Location (UCSC)Chr 7: 102.67 – 102.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.[3]

References

Further reading


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