POU2AF1

POU2AF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CQT
Identifiers
Aliases	POU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
External IDs	OMIM: 601206 MGI: 105086 HomoloGene: 4543 GeneCards: POU2AF1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	111,455,630 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	51,151,380 bp[2]
RNA expression pattern
	Top expressed in
	pylorus; ; cardia; ; spleen; ; lymph node; ; appendix; ; bronchial epithelial cell; ; thymus; ; bone marrow cells; ; cancellous bone; ; duodenum;
	Top expressed in
	spleen; ; submandibular gland; ; blood; ; female urethra; ; subcutaneous adipose tissue; ; duodenum; ; bone marrow; ; thymus; ; Paneth cell; ; detrusor urinae muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; protein binding; transcription coregulator activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; humoral immune response; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5450
	18985
	ENSG00000110777
	ENSMUSG00000032053
	Q16633
	Q64693
	NM_006235
	NM_011136
	NP_006226
	NP_035266
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.[5][6] The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.[7] BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.[8] The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,[9] as exemplified in studies which use BAB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.[10]

Interactions

POU2AF1 has been shown to interact with:

POU2F1[11][12][13] and
SIAH1.[14][15]

References

GRCh38: Ensembl release 89: ENSG00000110777 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032053 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.
"Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".
https://www.ncbi.nlm.nih.gov/gene?term=(ocab[gene])%20AND%20(Homo%20sapiens[orgn])%20AND%20alive[prop]%20NOT%20newentry[gene]&sort=weight
Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.
Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.
Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402. S2CID 53196244.
Chasman D, Cepek K, Sharp PA, Pabo CO (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.
Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH (March 2017). "TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1". Blood. 129 (10): 1284–1295. doi:10.1182/blood-2016-09-737536. PMID 28053195.

Teitell MA (2004). "OCA-B regulation of B-cell development and function". Trends Immunol. 24 (10): 546–53. doi:10.1016/j.it.2003.08.002. PMID 14552839.
Luo Y, Roeder RG (1995). "Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B". Mol. Cell. Biol. 15 (8): 4115–24. doi:10.1128/MCB.15.8.4115. PMC 230650. PMID 7623806.
Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM (1995). "A B-cell coactivator of octamer-binding transcription factors". Nature. 373 (6512): 360–2. Bibcode:1995Natur.373..360G. doi:10.1038/373360a0. PMID 7779176. S2CID 4303288.
Strubin M, Newell JW, Matthias P (1995). "OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins". Cell. 80 (3): 497–506. doi:10.1016/0092-8674(95)90500-6. PMID 7859290. S2CID 6139601.
Galiègue-Zouitina S, Quief S, Hildebrand MP, Denis C, Lecocq G, Collyn-d'Hooghe M, Bastard C, Yuille M, Dyer MJ, Kerckaert JP (1996). "Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation". Comptes Rendus de l'Académie des Sciences, Série III. 318 (11): 1125–31. PMID 8574789.
Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T (1997). "Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells". Science. 277 (5323): 221–5. doi:10.1126/science.277.5323.221. PMID 9211847.
Sauter P, Matthias P (1998). "The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction". Immunobiology. 198 (1–3): 207–16. doi:10.1016/S0171-2985(97)80041-1. PMID 9442392.
Luo Y, Ge H, Stevens S, Xiao H, Roeder RG (1998). "Coactivation by OCA-B: Definition of Critical Regions and Synergism with General Cofactors". Mol. Cell. Biol. 18 (7): 3803–10. doi:10.1128/mcb.18.7.3803. PMC 108964. PMID 9632764.
Sauter P, Matthias P (1998). "Coactivator OBF-1 Makes Selective Contacts with Both the POU-Specific Domain and the POU Homeodomain and Acts as a Molecular Clamp on DNA". Mol. Cell. Biol. 18 (12): 7397–409. doi:10.1128/MCB.18.12.7397. PMC 109321. PMID 9819426.
Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell. 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971. S2CID 14650955.
Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.
Boehm J, He Y, Greiner A, Staudt L, Wirth T (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMC 149152. PMID 11483518.
Malone CS, Wall R (2002). "Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters". J. Immunol. 168 (7): 3369–75. doi:10.4049/jimmunol.168.7.3369. PMID 11907094.
Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, Nussenzweig M (2003). "OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes". Cell. 110 (5): 575–85. doi:10.1016/S0092-8674(02)00911-X. PMID 12230975. S2CID 17887117.
Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.
Lins K, Reményi A, Tomilin A, Massa S, Wilmanns M, Matthias P, Schöler HR (2003). "OBF1 enhances transcriptional potential of Oct1". EMBO J. 22 (9): 2188–98. doi:10.1093/emboj/cdg199. PMC 156071. PMID 12727885.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110777 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032053 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8617501-5] Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501.

[entrez-6] "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1".

[7] ttps://www.ncbi.nlm.nih.gov/gene?term=(ocab[gene])%20AND%20(Homo%20sapiens[orgn])%20AND%20alive[prop]%20NOT%20newentry[gene]&sort=weight

[pmid17198308-8] Ponzoni M, Arrigoni G, Doglioni C (January 2007). "New transcription factors in diagnostic hematopathology". Advances in Anatomic Pathology. 14 (1): 25–35. doi:10.1097/PAP.0b013e31802f0495. PMID 17198308. S2CID 37644377.

[pmid27319306-9] Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z (November 2016). "Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers". Histopathology. 69 (5): 775–783. doi:10.1111/his.13017. PMID 27319306. S2CID 12613073.

[pmid30380402-10] Grimm KE, O'Malley DP (February 2019). "Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues". Annals of Diagnostic Pathology. 38: 6–10. doi:10.1016/j.anndiagpath.2018.09.014. PMID 30380402. S2CID 53196244.

[pmid10541551-11] Chasman D, Cepek K, Sharp PA, Pabo CO (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.

[pmid9418884-12] Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.

[pmid11380252-13] Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.

[pmid11483517-14] Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178. PMID 11483517.

[pmid28053195-15] Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH (March 2017). "TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1". Blood. 129 (10): 1284–1295. doi:10.1182/blood-2016-09-737536. PMID 28053195.

POU2AF1

Interactions

See also

References

Further reading