Phosphatidic acid phosphatase 2c

PLPP2
Identifiers
Aliases	PLPP2, LPP2, PAP-2c, PAP2-g, PPAP2C, Phosphatidic acid phosphatase 2c, phospholipid phosphatase 2
External IDs	OMIM: 607126 MGI: 1354945 HomoloGene: 2752 GeneCards: PLPP2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	291,403 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	79,369,630 bp[2]
RNA expression pattern
	Top expressed in
	right uterine tube; ; minor salivary gland; ; gallbladder; ; skin of abdomen; ; bronchial epithelial cell; ; middle frontal gyrus; ; rectum; ; duodenum; ; body of pancreas; ; stromal cell of endometrium;
	Top expressed in
	ileum; ; duodenum; ; crypt of lieberkuhn of small intestine; ; pyloric antrum; ; intestinal villus; ; jejunum; ; medullary collecting duct; ; left colon; ; epithelium of stomach; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; protein binding; lipid phosphatase activity; hydrolase activity; sphingosine-1-phosphate phosphatase activity; phosphatidate phosphatase activity; phosphatase activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	phospholipid metabolic process; sphingolipid biosynthetic process; phospholipid dephosphorylation; signal transduction; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8612
	50784
	ENSG00000141934
	ENSMUSG00000052151
	O43688
	Q9DAX2
	NM_003712; NM_177526; NM_177543
	NM_015817; NM_001302389; NM_001302390; NM_001302442
	NP_003703; NP_803545; NP_808211
	NP_001289318; NP_001289319; NP_001289371; NP_056632
	Wikidata
View/Edit Human	View/Edit Mouse

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.[5][6][7]

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

References

GRCh38: Ensembl release 89: ENSG00000141934 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000052151 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154.
Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. S2CID 31610109.
"Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID 12471011.
Morris KE, Schang LM, Brindley DN (2006). "Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts". J. Biol. Chem. 281 (14): 9297–306. doi:10.1074/jbc.M511710200. PMID 16467304.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang N, Sundberg JP, Gridley T (2000). "Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile". Genesis. 27 (4): 137–40. doi:10.1002/1526-968X(200008)27:4<137::AID-GENE10>3.0.CO;2-4. PMID 10992322. S2CID 24643785.
Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform". J. Biol. Chem. 273 (34): 22059–67. doi:10.1074/jbc.273.34.22059. PMID 9705349.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141934 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052151 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570154-5] Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154.

[pmid9607309-6] Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. S2CID 31610109.

[entrez-7] "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C".

Phosphatidic acid phosphatase 2c

References

Further reading