PPP2R2B

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.[5][6]

PPP2R2B
Identifiers
AliasesPPP2R2B, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12, protein phosphatase 2 regulatory subunit Bbeta
External IDsOMIM: 604325 MGI: 1920180 HomoloGene: 55833 GeneCards: PPP2R2B
Orthologs
SpeciesHumanMouse
Entrez

5521

72930

Ensembl

ENSG00000156475

ENSMUSG00000024500

UniProt

Q00005

Q6ZWR4

RefSeq (mRNA)

NM_027531
NM_028392

RefSeq (protein)

NP_082668
NP_081807
NP_001390894

Location (UCSC)Chr 5: 146.58 – 147.08 MbChr 18: 42.77 – 43.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000156475 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024500 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA (May 1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry. 30 (15): 3589–97. doi:10.1021/bi00229a001. PMID 1849734.
  6. Holmes SE, O'Hearn EE, McInnis MG, Gorelick-Feldman DA, Kleiderlein JJ, Callahan C, Kwak NG, Ingersoll-Ashworth RG, Sherr M, Sumner AJ, Sharp AH, Ananth U, Seltzer WK, Boss MA, Vieria-Saecker AM, Epplen JT, Riess O, Ross CA, Margolis RL (Dec 1999). "Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12". Nat Genet. 23 (4): 391–2. doi:10.1038/70493. PMID 10581021. S2CID 33491731.
  7. "Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform".

Further reading

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